Effect of Shigella toxin on preimplantation mouse embryos in vitro

Teratology
W M Olsen, R Storeng

Abstract

Preimplantation mouse embryos at the 4-cell to 8-cell stage were exposed to Shigella dysenteriae toxin at concentrations of 0.001-100 pg/ml in vitro. The effect of the toxin was studied by morphological observation of the embryos to the blastocyst stage, by assessing protein synthesis with 14C-leucine incorporation, and by measuring embryonic adenosine triphosphate (ATP) content. Preimplantation mouse embryos were highly sensitive to the toxin. All variables investigated were adversely influenced by the toxin. After a lag period of 24 hr, 0.01 pg/ml toxin inhibited development to the blastocyst stage and protein synthesis. Toxin concentrations of 1.0 pg/ml resulted in a significant decrease in ATP content.

References

Aug 9, 1976·Biochemical and Biophysical Research Communications·M R ThompsonB P Doctor
May 1, 1975·Fertility and Sterility·P S Bell, R H Glass
Sep 1, 1974·Genetics·D G Whittingham
Nov 1, 1983·Infection and Immunity·K Eiklid, S Olsnes
Dec 1, 1984·Hormones and Behavior·K L Olsen, R E Whalen
Aug 1, 1983·Journal of Toxicology and Environmental Health·R Storeng, J Jonsen
Jan 1, 1980·Journal of Receptor Research·K Eiklid, S Olsnes
Jan 1, 1981·Toxicology·R Storeng, J Jonsen

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Citations

Jun 1, 1987·Environmental Health Perspectives·T J Flynn
Sep 1, 1987·Pharmacology & Toxicology·W M Olsen, R Storeng
Apr 1, 1987·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·R Storeng, B Johne

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