Effect of short-acting nitroglycerin on heart rate: evaluation by a self-monitoring device

British Journal of Clinical Pharmacology
J T Lahtela, E A Sotaniemi

Abstract

The efficacy of two sublingual nitroglycerin formulations was compared in 10 healthy subjects and 10 patients with ischaemic heart disease. A new microcomputerized device was used to record and analyze heart rate. The rise in heart rate began 1-1.5 min after administration of nitroglycerin tablets and was maximal within 3 min. The effect was more rapid with a quickly dissolving compound. The recording equipment was reliable, simple to use and inexpensive.

References

Mar 1, 1986·Journal of Pharmaceutical Sciences·P K Noonan, L Z Benet
Sep 1, 1987·Clinical Pharmacology and Therapeutics·P K Noonan, L Z Benet
Jun 1, 1974·Journal of Pharmaceutical Sciences·A M ContractorR F Shangraw

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