Effect of short peptides on neuronal differentiation of stem cells

International Journal of Immunopathology and Pharmacology
Sergio CaputiV Kh Khavinson

Abstract

It has been demonstrated that short peptides play an important role in the transmission of biological information, modulation of transcription, and restoring genetically conditioned alterations occurring with age. Peptidergic regulation of homeostasis occupies an important place in physiological processes, which lead to the aging of cells, tissues, and organs, consisting in the involution of major regulatory systems-the nervous, the endocrine, and the immune. The effect of AED (Ala-Glu-Asp), KED (Lys-Glu-Asp), KE (Lys-Glu), AEDG (Ala-Glu-Asp-Gly) peptides and their compound on neuronal differentiation of human periodontal ligament stem cells (hPDLSCs) was studied by immunofluorescence and western blot analysis. Growth-Associated Protein 43 (GAP43), which implements neurotransmission mechanisms and neuroplasticity, demonstrated an increased expression in hPDLSCs cultured with a compound of all studied peptides and with KED alone. The peptide compound and KED, increase the expression of Nestin (neurofilament protein), expressed in early neuronal precursors in hPDLSCs cultures. Thus, the compound of peptides AEDG, KE, AED, and KED could promote the neuronal differentiation of hPDLSCs and be a promising tool for the study of peptid...Continue Reading

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Citations

Dec 7, 2019·Stem Cell Reviews and Reports·Vladimir KhavinsonSvetlana Trofimova
Nov 5, 2019·Stem Cell Reviews and Reports·Bruna SinjariSergio Caputi
Feb 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vladimir KhavinsonBruna Sinjari
Apr 5, 2020·Bulletin of Experimental Biology and Medicine·A Yu TerekhovV Kh Khavinson
May 14, 2020·Molecular Biology Reports·Vasily AshapkinBoris Vanuyshin
Nov 26, 2020·International Journal of Molecular Sciences·Rita RezzaniLuigi Fabrizio Rodella
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vasso ApostolopoulosIstvan Toth
Jun 27, 2021·Bulletin of Experimental Biology and Medicine·V Kh KhavinsonR S Umnov
Jun 18, 2021·World Journal of Stem Cells·Jing-Yao YinDan-Dan Ma
Nov 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vladimir Khatskelevich KhavinsonAnastasiia Romanovna Ilina

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Methods Mentioned

BETA
biopsies
scraping
flow cytometry
light microscopy
confocal microscopy

Software Mentioned

GraphPad Prism
Uvitec
GraphPad
TreeStar

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