Effect of short-term fasting on free/dissociable insulin-like growth factor I concentrations in normal human serum

The Journal of Clinical Endocrinology and Metabolism
A BereketC H Lang

Abstract

A small portion of circulating insulin-like growth factor I (IGF-I) is detected in the free or readily dissociable state, which is thought to be the metabolically active form. The amount of free/dissociable IGF-I in serum is dependent on a complex interplay between the production rate and the concentrations of IGF-I and IGF-binding proteins (IGFBPs). IGF availability is also influenced by posttranslational changes in IGFBPs that affect the affinity of IGFBPs for IGF-I. In the present study, we examined whether a short term fast (approximately 12 h) alters the serum concentration of free/dissociable IGF-I, and whether these changes are associated with alterations in IGFBP-1 and the proteolysis status of IGFBP-3. Circulating free/dissociable IGF-I concentrations, as assessed by a two-site immunoradiometric assay, did not differ between fasting and 4 h after a morning meal (1.48 +/- 0.07 vs. 1.50 +/- 0.07 microgram/L, respectively). Likewise, free/dissociable IGF-I levels measured by RIA after separation by centrifugal ultrafiltration were not different between the two groups (1.43 +/- 0.14 vs. 1.38 +/- 0.18 microgram/L, respectively). IGF-I bioactivity, as measured by thymidine incorporation by fibroblasts, did not differ in fast...Continue Reading

Citations

Aug 1, 1997·Endocrine·C F Estívariz, T R Ziegler
Sep 1, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jan Frystyk
Oct 29, 2014·International Journal of Cancer. Journal International Du Cancer·Yin CaoEdward L Giovannucci
Mar 31, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Peter BangJonas Nygren
May 5, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·José Manuel GómezJuan Soler

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