PMID: 6985836Jan 15, 1980Paper

Effect of short-term levamisole therapy on delayed hypersensitivity

Cancer
Y HirshautH F Oettgen

Abstract

A randomized trial of short-term Levamisole treatment was undertaken in a cancer population unresponsive to dinitrochlorobenzene (DNCB) to determine whether this agent increased delayed hypersensitivity. Of 100 patients entered, 50 received Levamisole (150 mg daily x 3) during DNCB challenge. The other 50 patients were challenged but not given the drug. The conversion rate to DNCB+ was 20% (10/50) for those treated and 12% (6/50) for controls. The difference is not significant. When all 100 patients were considered there was a statistically significant inverse relationship between extent of disease and the incidence of conversion to a DNCB reactive state. Levamisole as given does not appear to have a major influence on delayed cutaneous hypersensitivity.

References

Feb 1, 1977·The Journal of Experimental Medicine·G Renoux, M Renoux
Aug 1, 1975·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F SpreaficoS Garattini
Aug 16, 1973·The New England Journal of Medicine·D TripodiJ Brugmans
Dec 1, 1973·Life Sciences·J BrugmansE Stevens

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Citations

May 14, 1993·Cancer Letters·N K GuptaC Feit

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