PMID: 2487409Jan 1, 1989Paper

Effect of short-term prednisolone therapy in patients with severe chronic type B hepatitis

The Korean Journal of Internal Medicine
J Y YooW K Chung

Abstract

Ten patients with severe chronic type B hepatitis confirmed by liver biopsy were treated with prednisolone for eight weeks and followed up for more than one year. The patients were comprised of 6 males and 4 females, ages 17 to 45 (mean 32) yrs. Serum alanine aminotransferase (ALT) was elevated more than one month before the treatment in all (mean: 379 U/L, range: 87 to 772 U/L). Initial serological tests showed hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) in all and hepatitis B virus DNA (HBV-DNA) in 7/10 (70%). Liver biopsy showed severe chronic active hepatitis with confluent necrosis or acinar hepatitis in all. Prednisolone, 60 mg/day, was administered initially and the dose was tapered every 2 weeks over the 8 weeks period. Two to six months after cessation of treatment, 5 of 10 patients showed a disappearance of HBeAg and serum HBV-DNA and return of serum ALT level to normal (responders). The initial serum ALT level in responders was slightly higher than that of non-responders (mean: 404 vs. 355 U/L), but there was no statistical significance. Among 5 responders, serum HBV-DNA was detected in three patients initially and was transiently detected in one patient during treatment. In non-responders, ...Continue Reading

References

Nov 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P V NairC Boone
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N V NaumovR Williams
Sep 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E SagnelliC M Izzo
Feb 12, 1981·The New England Journal of Medicine·K C LamP C Wu
Apr 1, 1982·Annals of Internal Medicine·J H HoofnagleJ Costa

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