PMID: 2105988Mar 1, 1990Paper

Effect of short-term prostacyclin administration on restenosis after percutaneous transluminal coronary angioplasty

Journal of the American College of Cardiology
M L KnudtsonH J Duff

Abstract

The effect of short-term prostacyclin (PGI2) administration on the incidence of restenosis after coronary angioplasty was studied in a prospective single-blind randomized trial of 286 patients. Of the 270 patients in whom dilation was successful, 134 received prostacyclin and 136 received placebo. Intracoronary prostacyclin was administered before and after dilation and then intravenously for 48 h. The control group received intracoronary placebo infusions before and after dilation. All patients received aspirin and dipyridamole before and after angioplasty, at least until follow-up angiography. Follow-up angiograms were obtained in 93% of patients in whom angioplasty was successful. Restenosis of one or more lesions was present in 34 patients (27%) who were given prostacyclin compared with 40 patients (32%) in the control group (p = NS). Acute vessel closure and ventricular tachyarrhythmias were more common in the control group than in the patients who received prostacyclin (acute vessel closure occurred in 14 [10.3%] of 136 versus 4 [3.0%] of 134, respectively, p less than 0.01; ventricular tachyarrhythmias occurred in 5 [3.4%] of 147 versus 0 of 139 respectively, p less than 0.05). Short-term administration of prostacyclin d...Continue Reading

References

Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·B B WekslerE A Jaffe
Aug 20, 1979·Life Sciences·G A FitzGeraldP J Lewis
Jan 1, 1979·Haemostasis·S Moncada, J L Amezcua
Jan 1, 1979·Thrombosis Research·E G Levin, D J Loskutoff
Dec 1, 1986·Journal of the American College of Cardiology·H B WhitworthA R Gruentzig
Jul 31, 1987·The American Journal of Cardiology·J H ChesebroV Fuster
Jun 1, 1987·Thrombosis Research·K WintherS Medgyesi
Sep 1, 1982·Journal of Cardiovascular Pharmacology·V A StarnesJ W Hammon
Mar 1, 1983·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·B AdelmanR I Handin
Jan 26, 1984·The New England Journal of Medicine·J H ChesebroF J Puga
May 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J Grünwald, C C Haudenschild
Aug 1, 1982·British Journal of Clinical Pharmacology·H Pickles, J O'Grady
Mar 1, 1980·The American Journal of Cardiology·R C PasternakP C Block

Citations

May 1, 1991·Journal of the American College of Cardiology·D R HolmesM W Webster
Nov 11, 1992·Journal of the American College of Cardiology·R S SchwartzE J Topol
Feb 1, 1992·Journal of the American College of Cardiology·R S SchwartzD R Holmes
Feb 1, 1993·Journal of the American College of Cardiology·J Y LamV Fuster
Jan 1, 1993·Journal of the American College of Cardiology·R E KuntzD S Baim
May 1, 1994·Journal of the American College of Cardiology·J G WiedermannJ Weinberger
Jan 1, 1995·Micron : the International Research and Review Journal for Microscopy·D A Handley
Aug 23, 2002·European Journal of Pharmacology·Rüdiger BlindtJ Meyer-Kirchrath
Jul 1, 1995·Progress in Cardiovascular Diseases·L Schwartz, P H Seidelin
Nov 5, 1997·Progress in Cardiovascular Diseases·J Lefkovits, E J Topol
Dec 1, 2001·Pharmacology & Therapeutics·M R Bennett, M O'Sullivan
Mar 28, 2002·Pharmacology & Therapeutics·S M GarasN A Scott
Apr 8, 1998·Journal of the American College of Cardiology·R G Favaloro
Apr 7, 1994·The New England Journal of Medicine·C LandauL D Hillis
Aug 6, 1993·Journal of Interventional Cardiology·H V AndersonJ T Willerson
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Stefan Peters
May 29, 1999·International Journal of Radiation Oncology, Biology, Physics·M M MarijianowskiK A Robinson
Apr 16, 1998·Journal of Vascular and Interventional Radiology : JVIR·D A Diamond, T M Vesely
Mar 3, 1998·Blood Reviews·J E Joseph, S J Machin
Nov 7, 1998·Current Problems in Cardiology·W H FrishmanM Weiss
May 10, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M HeiseU Settmacher
Oct 1, 1993·The American Journal of the Medical Sciences·R A LangeL D Hillis
Nov 18, 2000·FEBS Letters·S M NiliusJ Meyer-Kirchrath

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.