PMID: 22359978Mar 1, 2012Paper

Effect of short-term standard therapeutic regimens on neuropeptide Y and adipose tissue hormones in overweight insulin-resistant women with polycystic ovary syndrome

Folia medica
Maria M OrbetzovaGencho D Genchev

Abstract

The study was aimed at elucidating the influence of a 3-month treatment with routine therapeutic regimens--oral hormonal contraceptives (OHC) with antiandrogenic activity (a standard combination of ethynil estradiol 35 microg plus cyproterone acetate 2 mg) in combination with insulin sensitizing agents--metformin (Group I) and rosiglitazone (Group II) on adipose tissue hormones and hypothalamic neuropeptide Y (NPY) in women with polycystic ovary syndrome. The study included 66 overweight insulin resistant women with PCOS according to the recent ESHRE-ASRM criteria randomized into 2 age-matched therapeutic groups. Significant decrease of leptin (P < 0.01; P = 0.001, resp.), resistin (P < 0.01; P < 0.01, resp.), tumour necrosis factor alpha (TNF alpha) (P = 0.001; P < 0.001, resp.), and NPY (P < 0.05; P < 0.001, resp.) was observed in both groups after treatment. These findings were in parallel with a significant decrease in the anthropometric parameters of body weight in the metformin group only. No significant changes in hormonal characteristics of the groups were found except for a significant decrease in androstenedione and DHEA-S (P < 0.05) in the metformin group and in 17-OH-progesterone (P < 0.05) in the rosiglitazone grou...Continue Reading

References

May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·G S HotamisligilB M Spiegelman
May 28, 1993·Annals of the New York Academy of Sciences·I M Golland, M E Elstein
Feb 1, 1997·Clinical Endocrinology·G GennarelliT Bäckström
Jun 25, 1998·The New England Journal of Medicine·J E NestlerR Pasquali
Jun 3, 1999·Endocrinology and Metabolism Clinics of North America·R S Rittmaster
Dec 22, 1999·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·B BaranowskaA Płonowski
Jan 25, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·M RajkhowaA H Balen
Jun 25, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A GambineriR Pasquali
Dec 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Uberto PagottoRenato Pasquali
Feb 8, 2003·The Journal of Clinical Endocrinology and Metabolism·L J MoranR J Norman
Jul 10, 2003·Fertility and Sterility·William U AtiomoPaul Hardiman
Aug 12, 2003·Fertility and Sterility·Ricardo Azziz
Dec 23, 2003·Human Reproduction·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
Jan 9, 2004·Fertility and Sterility·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Ricardo AzzizBulent O Yildiz
Sep 10, 2004·The Journal of Clinical Endocrinology and Metabolism·Abhimanyu Garg
Nov 13, 2004·The Journal of Clinical Endocrinology and Metabolism·V JayagopalS L Atkin
Jan 1, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·P M LamC Haines
Feb 16, 2005·Circulation·Muredach P ReillyDaniel J Rader
Mar 11, 2005·European Journal of Endocrinology·E CarminaR A Lobo
Jun 22, 2005·Treatments in Endocrinology·Carla Pelusi, Renato Pasquali
Dec 13, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Murat YilmazMetin Arslan
May 6, 2006·Human Reproduction·H F Escobar-MorrealeJ L San Millán
Aug 19, 2006·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Kimberly E LiuMargaret Sagle
Jan 31, 2007·Human Reproduction·Michael F CostelloPeter Sjoblom
Feb 9, 2007·The New England Journal of Medicine·Richard S LegroUNKNOWN Cooperative Multicenter Reproductive Medicine Network
Feb 24, 2007·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·S HahnO E Janssen
Aug 19, 2007·Trends in Endocrinology and Metabolism : TEM·Héctor F Escobar-Morreale, José L San Millán
Oct 30, 2007·The Medical Clinics of North America·Michael Magnotti, Walter Futterweit
Nov 29, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E Diamanti-Kandarakis
Nov 6, 2007·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Carmen N MirceaRoger A Pierson
Oct 22, 2008·The Journal of Obstetrics and Gynaecology Research·Aysun BideciPeyami Cinaz
Jun 27, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Vasiliki VervitaNeoklis A Georgopoulos

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Citations

Oct 22, 2016·Archives of Physiology and Biochemistry·Daniela Iv KolevaStefan B Tyutyundzhiev
May 16, 2014·Fertility and Sterility·Andrea MorcianoRosanna Apa
Aug 15, 2020·The Cochrane Database of Systematic Reviews·Eloise FraisonMichael F Costello

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