PMID: 7927919Oct 15, 1994Paper

Effect of sialoadenectomy on medroxyprogesterone-acetate-induced mammary carcinogenesis in BALB/c mice. Correlation between histology and epidermal-growth-factor receptor content

International Journal of Cancer. Journal International Du Cancer
E KordonC Lanari

Abstract

To evaluate the possible involvement of the salivary glands in the modulation of medroxyprogesterone (MPA)-induced mammary tumorigenesis, 48 sialoadenectomized virgin BALB/c female mice and 47 controls were treated with 40mg MPA depot s.c. every 3 months for 1 year. Mammary tumors developed in 11 sialoadenectomized and in 34 control mice with similar latencies. In both groups, 75% of the tumors were ductal and progestin-dependent (PD) while the remainder were lobular and progestin-independent (PI). Epidermal growth factor (EGF) levels were measured in salivary glands (SG-EGF) and serum (S-EGF) in both groups. MPA induced a significant increase in SG-EGF and in S-EGF that became evident only after 1 month of MPA treatment. No increase in S-EGF was detected in MPA-treated sialoadenectomized mice, indicating that salivary glands are the major source of S-EGF. The presence of EGF receptors (EGF-R) was investigated in ductal PD and PI tumor lines and compared with 8 PI tumor lines of lobular origin. A significant difference in EGF-R content was found between lobular and ductal tumors. No increase in EGF-R was noted when ductal tumors became autonomous. EGF-R did not correlate with tumor growth rate and there was an inverse correlati...Continue Reading

References

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Citations

Aug 5, 2008·Breast Cancer Research and Treatment·Victoria WargonClaudia Lanari
Jul 29, 2008·Journal of Mammary Gland Biology and Neoplasia·Edith C Kordon
Mar 22, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Luisa A HelgueroClaudia Lanari
Apr 24, 1999·The Journal of Steroid Biochemistry and Molecular Biology·M F MontecchiaC Lanari
Jul 29, 1999·Breast Cancer Research and Treatment·M F MontecchiaC Lanari
Oct 2, 2002·Breast Cancer Research and Treatment·Valeria BuggianoEdith C Kordon
Jun 5, 2003·Breast Cancer Research and Treatment·Caroline A LambClaudia Lanari
Jun 2, 2021·Essays in Biochemistry·Sebastian GiulianelliClaudia Lanari

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