Effect of side group chemistry on the properties of biodegradable L-alanine cosubstituted polyphosphazenes

Biomacromolecules
Anurima SinghH R Allcock

Abstract

Biodegradable polyphosphazenes have been investigated for a variety of applications, such as controlled drug delivery matrixes, tissue-engineering scaffolds, membranes, and bone-type composites. In this study we have evaluated the effect of side group chemistry on the properties of biodegradable phosphazene polymers that contain ethyl alanato side groups together with ethyl glycinato, p-methylphenoxy, or p-phenylphenoxy side groups. The polymers were synthesized by a macromolecular substitution route. The molecular weights of aryloxy/amino acid ester cosubstituted polymers were much higher than the amino acid ester substituted polyphosphazenes described earlier. Polymer properties, such as glass transition temperature, hydrolytic degradation, surface wettability, tensile strength, and modulus of elasticity varied over a wide range following changes to the type of co-substituents on the polymer backbone. The glass transition temperatures varied from -10 to 35 degrees C and increased with the bulkiness of the side groups. Polymer films in phosphate buffer saline solution showed molecular weight declines ranging from 58% to >80% and mass loss ranging from 4% to 90% over a period of 7 weeks. Water contact angles for polymer films v...Continue Reading

References

Oct 31, 2000·Biomaterials·J C Middleton, A J Tipton
Apr 23, 2003·Advanced Drug Delivery Reviews·S LakshmiC T Laurencin
Nov 11, 2003·Biomacromolecules·Ann-Christine Albertsson, Indra K Varma
Nov 25, 2004·Advanced Drug Delivery Reviews·Harjit TamberBruno Gander

❮ Previous
Next ❯

Citations

Apr 26, 2008·Journal of Materials Science. Materials in Medicine·Y E GreishP W Brown
Jun 4, 2008·Biomacromolecules·Syam P NukavarapuCato T Laurencin
Apr 14, 2007·Tissue Engineering·James D Kretlow, Antonios G Mikos
Jun 26, 2013·Acta Crystallographica. Section E, Structure Reports Online·Muhammet IşıklanTuncer Hökelek
Jul 16, 2013·Acta Biomaterialia·Tao JiangCato T Laurencin
Jun 3, 2014·BioMed Research International·Amanda L Baillargeon, Kibret Mequanint
May 7, 2010·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Aytuğ OkumuşFiliz Yilmaz
Dec 29, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Justin L BrownCato T Laurencin
Jul 20, 2011·Journal of Polymer Science. Part B, Polymer Physics·Bret D UleryCato T Laurencin
Sep 13, 2012·Journal of Biomedical Materials Research. Part a·Liyan QiuQinghe Zhao
Jan 24, 2009·Journal of Biomedical Materials Research. Part a·Meng DengCato T Laurencin
Aug 24, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Jing XuLiyan Qiu
Mar 20, 2008·The Journal of Bone and Joint Surgery. American Volume·Yusuf KhanCato T Laurencin
Sep 25, 2019·Pharmaceutics·Giuseppe CirilloFrancesca Iemma
Apr 21, 2020·Journal of Vacuum Science and Technology. B, Nanotechnology & Microelectronics : Materials, Processing, Measurement, & Phenomena : JVST B·Kenneth S OgueriCato T Laurencin
Apr 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paul Strasser, Ian Teasdale
Jun 10, 2017·Regenerative Engineering and Translational Medicine·Kenneth S OgueriCato T Laurencin
Mar 7, 2007·Biomacromolecules·Nicholas R KrogmanHarry R Allcock
Jan 26, 2010·Biomacromolecules·Preeti Shrinivas, Stefan Kasapis
May 29, 2015·ACS Applied Materials & Interfaces·Zhongjing Li, Harry R Allcock

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioremediation (ASM)

Bioremediation is the treatment and removal of harmful pollutants or contaminants through the use of microorganisms. Discover the latest research here.