Effect of sildenafil on gastric emptying and postprandial frequency of antral contractions in healthy humans

Scandinavian Journal of Gastroenterology
J L MadsenJ Graff

Abstract

Sildenafil is known to block phosphodiesterase type 5, which degrades nitric oxide-stimulated cyclic guanosine monophosphate, thereby relaxing smooth muscle cells in various organs. The effect of sildenafil on gastric motor function after a meal was investigated in healthy humans. Ten healthy male volunteers (21-28 years) participated in a placebo-controlled, double-blind, cross-over study. In random order and on two separate days each volunteer ingested either 50 mg sildenafil (Viagra, Pfizer, New York, N.Y., USA) or placebo. A gamma camera technique was used to measure gastric emptying and postprandial frequency of antral contractions. The area under the curve of gastric retention versus time of liquid or solid radiolabelled marker was not changed by sildenafil intake, nor was the postprandial frequency of antral contractions affected by sildenafil. A single dose of 50 mg sildenafil does not change gastric emptying or postprandial frequency of antral contractions in healthy volunteers.

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Citations

Mar 4, 2005·Clinical and Experimental Pharmacology & Physiology·Paula Vasconcelos AraújoPedro Jorge Caldas Magalhães
Feb 16, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H ZhuJ D Z Chen
Nov 1, 2005·Expert Opinion on Investigational Drugs·Brendan J R Whittle
Mar 24, 2006·Southern Medical Journal·Bumin DegirmenciEnder Ellidokuz
Oct 13, 2005·Current Opinion in Gastroenterology·Jan Tack
Jul 20, 2018·United European Gastroenterology Journal·F Carbone, J Tack
Oct 22, 2008·Scandinavian Journal of Gastroenterology·Pieter JanssenLeif Hultin

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