Effect of silicon-doped calcium phosphate bone grafting materials on bone regeneration and osteogenic marker expression after implantation in the ovine scapula

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Christine KnabeChristian Müller-Mai

Abstract

Compared to the currently clinically available bone grafting materials for alveolar ridge augmentation, there is a great demand for bioactive bone substitutes with higher resorbability, which enhance osteogenesis at the same time. This has prompted the development of a silicon-doped rapidly resorbable calcium alkali orthophosphate (Si-CAOP) and silicon-doped β-tricalcium phosphate (Si-TCP). This study evaluated the effect of these two particulate graft materials as compared to the currently clinically used β-TCP on bone formation and osteogenic marker expression after 2 weeks, 1, 3, 6, 12, and 18 months of implantation in critical size defects in the sheep scapula. Immunohistochemical analysis of collagen type I, alkaline phosphatase, and osteocalcin expression was performed on resin embedded sections. The bone and particle area fraction and the bone-biomaterial contact were determined histomorphometrically. After 2 weeks and 1 month defects grafted with Si-CAOP displayed a significantly greater bone area fraction, bone-particle-contact, osteogenic marker expression and significantly lower particle area fraction than defects grafted with Si-TCP and TCP. By 3 and 6 months all materials studied mediated excellent defect regenerat...Continue Reading

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Citations

Oct 15, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Manish KumarSanjeevi Kannan
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·F KermaniJ Vahdati Khaki
Feb 23, 2021·Macromolecular Bioscience·Yi ZhuAnnie Shrestha
Jun 15, 2021·Dental Materials Journal·Marion LabussiereXavier Struillou

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