Effect of silicon doping on bone formation within alumina porous domains

Journal of Biomedical Materials Research. Part a
Moreica B PabbruweC Rolfe Howlett

Abstract

The effect of doping a porous bioinert bioceramic with silicon (Si) on tissue ingrowth, differentiation, and osteogenesis was studied using a rat intramedullary model. Alumina tubes (1.3-mm outer diameter, 0.6-mm inner diameter, 15-mm length) doped with Si at nominal concentrations of 0.5 and 5.0 mol % were implanted into femoral medullary canals of female rats for 16 weeks. Tissue formation within the tubes was determined by histology and histomorphometry. Addition of 0.5 mol % Si to alumina stimulated cellular activity at the bone-ceramic interface and impaired osteogenic maturation within the tubes. In contrast, osteogenesis was enhanced in the 5.0 mol % Si-doped alumina tubes. It is considered that effect of Si is related to surface chemistry rather than microstructure. This work demonstrates that doping a bioinert ceramic with small amounts of Si can significantly alter tissue ingrowth, differentiation, and osteogenesis within a porous implant.

References

Nov 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P E KeetingB L Riggs
Apr 1, 1987·The Journal of Nutrition·R M Leach, C V Gay
Jan 1, 1987·The Journal of Nutrition·B J FriedmanS D Houston
Jan 1, 1986·The Journal of Nutrition·L G StrauseD Resnick
Nov 10, 1972·Science·E M Carlisle
Jan 1, 1981·Calcified Tissue International·E M Carlisle
Feb 1, 1980·The Journal of Nutrition·E M Carlisle
Sep 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H ZhouK W Ng
Sep 1, 1993·Calcified Tissue International·M HottP J Marie
Aug 1, 1993·Journal of the American College of Nutrition·P D Saltman, L G Strause
Nov 5, 1997·Critical Reviews in Toxicology·M Costa
Oct 6, 1972·Nature·K Schwarz, D B Milne
Jan 6, 2004·Journal of Biomedical Materials Research. Part a·Moreica B PabbruweC Rolfe Howlett
Apr 28, 2004·Biomaterials·Moreica B PabbruweC Rolfe Howlett

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Citations

Jul 17, 2007·The Spine Journal : Official Journal of the North American Spine Society·Karin A HingThomas Buckland
Jan 15, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Ather Farooq KhanAbdur Rahman Khan
Nov 11, 2020·ACS Applied Materials & Interfaces·Jose D AvilaAmit Bandyopadhyay

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