Effect of silver-loaded PMMA on Streptococcus mutans in a drip flow reactor

Journal of Biomedical Materials Research. Part a
Dustin L WilliamsRyan D Jolley

Abstract

Orthodontic retention has been proposed as a life-long commitment for patients who desire to maintain straight teeth. However, the presence of foreign material increases risk of bacterial colonization and caries formation, of which Streptococcus mutans is a key contributor. Multiple studies have assessed the ability of silver to be added to base plate material and resist attachment of S. mutans. However, it does not appear that long-term washout in connection with biofilm growth under physiologically relevant conditions has been taken into consideration. In this study, silver was added to base plate material and exposed to short- or long-term washout periods. Materials were then assessed for their ability to resist biofilm formation of S. mutans using a drip flow reactor that modeled the human oral environment. Data indicated that silver was able to resist biofilm formation following short-term washout, but long-term washout periods resulted in a lack of ability to resist biofilm formation. These data will be important for future development of base plate materials to achieve long-term antimicrobial efficacy to reduce risk of caries formation and benefit patients in the long term. © 2017 Wiley Periodicals, Inc. J Biomed Mater R...Continue Reading

References

Jan 1, 1975·Annual Review of Microbiology·R J Gibbons, J V Houte
Jun 1, 1989·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·W S Parker
May 23, 1998·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·C Melrose, D T Millett
Aug 2, 2005·Clinical Orthopaedics and Related Research·J William Costerton
Aug 29, 2006·Chemical Society Reviews·Evan M Hetrick, Mark H Schoenfisch
Nov 30, 2006·Advances in Skin & Wound Care·Richard Sal Salcido
Jun 15, 2007·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Fernanda Campos Rosetti LessaPaulo Nelson-Filho
Jun 17, 2009·Antimicrobial Agents and Chemotherapy·Serge RudenAnne S Ulrich
Jul 2, 2009·Surgical Infections·J Wesley Alexander
Feb 16, 2010·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Manish Valiathan, Eric Hughes
May 11, 2010·Canadian Journal of Microbiology·Fabrizio RivardoHoward Ceri
Jun 15, 2010·Plastic Surgical Nursing : Official Journal of the American Society of Plastic and Reconstructive Surgical Nurses·Marcia Spear
Nov 30, 2010·Dental Materials : Official Publication of the Academy of Dental Materials·Catherine FanKyumin Whang
Jan 8, 2014·Antimicrobial Agents and Chemotherapy·Dustin L WilliamsRoy D Bloebaum
Feb 2, 2016·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Nasrin FarhadianAmirfarhang Miresmaeili

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