Effect of silybin dihemisuccinate on the ethanol metabolizing systems of the rat liver

Cell Biochemistry and Function
A ValenzuelaR Guerra

Abstract

Silybin dihemisuccinate produces a decrease in the ethanol metabolic rate of rats. This effect is ascribed to an inhibition of the microsomal ethanol oxidizing system (MEOS). Alcohol dehydrogenase activity, catalase activity and NADPH cytochrome c reductase activity are not affected by the flavonoid. It is proposed that the inhibition of MEOS by silybin dihemisuccinate is related to its antioxidant properties, acting as a scavenger of the free radicals involved in ethanol metabolism by this enzymatic system. This observation may have therapeutical implications because microsomal lipid peroxidation induced by hydroxyl free radicals has been related to the etiology of hepatic alcoholic disease.

References

Jan 31, 1985·Biochemical and Biophysical Research Communications·A ValenzuelaA Garrido
Feb 1, 1972·European Journal of Biochemistry·R G ThurmanR Scholz
Feb 11, 1982·Biochemical and Biophysical Research Communications·L A VidelaA Valenzuela

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Citations

Apr 1, 1994·Chemico-biological Interactions·M P MiguezK O Lindros
Aug 14, 2003·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Jos F van PeltJohan Fevery
Feb 1, 1991·Journal of Applied Toxicology : JAT·S J HermanskyK A Mereish
Nov 26, 2015·Environmental Toxicology and Pharmacology·Nafiseh Sadat AlamolhodaeiGholamreza Karimi
Jun 9, 2005·Journal of Clinical Gastroenterology·Karen R Ball, Kris V Kowdley
May 25, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Chitra SridarPaul F Hollenberg

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