PMID: 7090001Apr 1, 1982Paper

Effect of silybin on phalloidin-actin interactions in vitro

Toxicology Letters
A LorangerB Tuchweber

Abstract

The possible antagonism between silybin and phalloidin an F-actin has been examined in vitro. Phalloidin protects F-actin against denaturation by potassium iodine, cytochalasin B, DNase and pronase. Silybin does not counteract the effect of phalloidin on F-actin. However, silybin alone slowed the rate of polymerization of actin, but this effect was moderate and obtained with very high concentrations. These results indicate that the site of action in vitro of silybin is not actin.

References

Aug 19, 1975·Biochimica Et Biophysica Acta·P DanckerT Wieland
May 14, 1976·Biochimica Et Biophysica Acta·I Löw, P Dancker
Jan 1, 1979·Canadian Journal of Biochemistry·J M Pollender, J Gruda
Nov 1, 1979·Toxicology and Applied Pharmacology·B TuchweberW Trost
Jul 20, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·E PetzingerM Frimmer
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·M Frimmer

Citations

Apr 1, 1994·Chemico-biological Interactions·M P MiguezK O Lindros
Aug 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·L A Sainz-PardoK O Lindros
May 1, 1984·Toxicology and Applied Pharmacology·G VogelU Mengs
Aug 27, 2013·Polish Journal of Veterinary Sciences·L RadkoW Rzeski

Related Concepts

Isoactin
Cytochalasin B
Alkaline DNase
Drug Stability
Bioflavonoids
Hydrolysis
Oligopeptides
Phalloidine
Pronase
Legalon

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