Effect of simple spike firing mode on complex spike firing rate and waveform in cerebellar Purkinje cells in non-anesthetized mice

Neuroscience Letters
L ServaisG Cheron

Abstract

Cerebellar Purkinje cells receive two different excitatory inputs from parallel and climbing fibers, causing simple and complex spikes, respectively. Purkinje cells present three modes of simple spike firing, namely tonic, silent and bursting. The influence of complex spike firing on simple spike firing has been extensively studied. However, it is unknown whether and how the simple spike firing mode may influence complex spike waveform and firing rate in vivo. We studied complex spike firing during tonic and silent mode periods in non-anesthetized mice. We found that complex spike firing rate is not influenced by simple spike firing modes, but that the complex spike waveform is altered following high frequency simple spike firing. This alteration is a specific decrement of the second depolarizing component of the complex spike. We demonstrate that the amplitude of the second depolarizing component is inversely proportional to the simple spike firing rate preceding the complex spike and that this amplitude is independent of previous complex spike firing. This waveform modulation is different from previously reported modulation in paired-pulse depression and refractoriness.

References

Jan 1, 1989·Annual Review of Neuroscience·M Ito
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Feb 13, 2003·Annals of the New York Academy of Sciences·Matthew T SchmoleskyChristian Hansel
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Citations

Mar 25, 2008·Neuroscience·G CheronB Dan
Jun 5, 2013·The European Journal of Neuroscience·Reinoud Maex, Volker Steuber
Dec 10, 2013·Neural Plasticity·Guy CheronJavier Márquez-Ruiz
Apr 29, 2015·Frontiers in Cellular Neuroscience·Pascal WarnaarErik De Schutter
Sep 26, 2009·Neuron·Eran A MukamelMark J Schnitzer
Oct 28, 2014·Frontiers in Systems Neuroscience·Gokhan OrdekMesut Sahin
Jun 4, 2016·The Cerebellum·Ronit Givon-MayoOpher Donchin
Mar 29, 2006·Nature Neuroscience·Martijn SchonewilleChris I De Zeeuw
Aug 24, 2005·The European Journal of Neuroscience·L ServaisG Cheron
May 7, 2020·Journal of Neurophysiology·Akshay MarkandayPeter Thier
Aug 26, 2021·Journal of Neurophysiology·Ehsan Sedaghat-NejadReza Shadmehr

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