PMID: 2484397Apr 1, 1989Paper

Effect of simulated American, Bulgarian, and Japanese human diets and of selenium supplementation on the incidence of virally induced mammary tumors in female mice

Biological Trace Element Research
G N SchrauzerD Waller

Abstract

In attempts to simulate the effects of diet on human breast cancer development groups of female C3H mice infected with mammary tumor virus (MMTV-) were maintained on diets formulated to resemble the typical American, Bulgarian, and Japanese human diets. The incidence of mammary tumors was the highest (84%) in group of mice receiving the simulated meat- and fat-rich American diet, which was also low in selenium (Se content: 0.15 ppm). The appearance of mammary tumors was delayed in the mice maintained on the simulated Bulgarian diet, and the final tumor incidence (27%) paralleled the correspondingly lower Bulgarian breast cancer incidence. The simulated Bulgarian diet contained more Se (0.25 ppm), and was lower in fat, meat, and sugar and higher in complex carbohydrates (cereals) than the simulated American diet. In the mice fed the simulated Japanese diet, the appearance of mammary tumors was also delayed, and the tumor incidence was diminished to 47%. In this diet, fish meal was a major source of Se, which is known to have low bioavailability. Additional supplementation of the Japanese-type diet with bioavailable Se (1 ppm) lowered the tumor incidence to 10%. Based on these studies, recommendations are made for breast cancer r...Continue Reading

References

Nov 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·S H WaxlerS L Beal
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Jun 23, 1962·Nature·M J LYONS, D H MOORE
Sep 1, 1981·Biological Trace Element Research·G N SchrauzerD Hamm

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Citations

Jan 1, 1997·Biological Trace Element Research·E W TaylorC S Ramanathan
Jun 12, 2009·Critical Reviews in Biotechnology·G N Schrauzer
Oct 22, 2011·Journal of Experimental Botany·Dun-Xian TanRussel J Reiter

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