Effect of Simulated Geomagnetic Activity on Myocardial Ischemia/Reperfusion Injury in Rats

Brazilian Journal of Cardiovascular Surgery
Hui WuLiang Dong

Abstract

To study the response of myocardial ischemia/reperfusion injury (MI/RI) in rats to simulated geomagnetic activity. In a simulated strong geomagnetic outbreak, the MI/RI rat models were radiated, and their area of myocardial infarction, hemodynamic parameters, creatine kinase (CK), lactate dehydrogenase (LDH), melatonin, and troponin I values were measured after a 24-hour intervention. Our analysis indicates that the concentrations of troponin I in the geomagnetic shielding+operation group were lower than in the radiation+operation group (P<0.05), the concentrations of melatonin in the shielding+operation group and normal+operation group were higher than in the radiation + operation group (P<0.01), and the concentrations of CK in the shielding + operation group were lower than in the radiation + operation group and normal + operation group (P<0.05). Left ventricular developed pressure (LVDP) and ± dP/dtmax in the radiation+operation group were lower than in the shielding + operation group and normal+operation group (P<0.01). Left ventricular end-diastolic pressure (LEVDP) in the shielding + operation group was higher than in the normal + operation group (P<0.05). There was no significant difference in area of myocardial infarcti...Continue Reading

Citations

Mar 6, 2021·Chronobiology International·David J Kennaway

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )

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