Jul 28, 2005

Effect of simvastatin on cardiac fibrosis in patients with essential hypertension

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Guo-Gang Zhang, Sai-Dan Zhang


To explore the effect of simvastatin on myocardiac fibrosis in patients with essential hypertension (EH). Sixty EH patients were randomly assigned into 2 groups: Benazepril (10 mg/d) group (n = 28) and simvastatin (20 mg/d) + benazepril (10 mg/d) group. Procollagen type III aminoterminal peptide (PIIIP), and procollagen type IV aminoterminal peptide (PIVP) levels in serum as well as transforming growth factor beta 1 (TGFbeta1) level in plasma were measured by radioimmunoassay (RIA) before and 6 months after the treatment. Doppler ultrasound recordings were obtained from all patients before and 6 months after the treatment to determine several parameters related to the left ventricular anatomy and function. After 6 month of treatment, the mean blood pressure (MBP), PIIIP, PIVP, TGFbeta1, left ventricular mass index (LVMI), interventricular spectum dimension (IVSD), and left ventricular posterio wall dimension (LPWD) in the 2 groups were significantly lower than those before the treatment. TGFbeta1 decreased in the simvastatin and benazepril group compared with the benazepril group (P < 0.01). The ratio of early diastolic blood flow velocity of mitral valve (VE) and blood flow velocity of atrium systolic period (VA) in the 2 grou...Continue Reading

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Mentioned in this Paper

Enzyme Inhibitor Drugs
Mitral Valve
Transforming Growth Factor Beta 1
Essential Hypertension
Blood Flow
TGFB1 gene

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