Effect of Simvastatin Prodrug on Experimental Periodontitis

Journal of Periodontology
Aaron D BradleyRichard A Reinhardt

Abstract

Local application of statins has shown potential in preventing and regenerating bone loss associated with experimental periodontitis. This study evaluates the effect of a novel simvastatin (SIM) prodrug (capable of delivering high doses to periodontitis inflammatory lesion and cells) on experimental periodontitis bone loss and inflammation. Forty mature female Sprague Dawley rats were subjected to ligature-induced experimental periodontitis between maxillary first and second molars (M1-M2). Equal groups were treated with three weekly doses of: 1) prodrug carrier alone (mPEG); 2) 0.5 mg SIM dose equivalent in carrier (SIM/SIM-mPEG); 3) 1.0 mg SIM/SIM-mPEG; 4) 1.5 mg SIM/SIM-mPEG; or 5) ligature alone. Contralateral molars served as unmanipulated controls. Four weeks after initiation of periodontitis, animals were euthanized, the M1-M2 interproximal was evaluated with microcomputed tomography and histology, and data were analyzed with one-way analysis of variance. Ligature alone caused a mean bone loss of 1.01 ± 0.06 mm from the cemento-enamel junction, whereas all doses of SIM/SIM-mPEG reduced bone loss, especially 1.5 mg SIM/SIM-mPEG (0.68 ± 0.05 mm, P <0.001), which was not statistically different from contralateral control (0...Continue Reading

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Citations

Apr 26, 2017·Journal of Periodontology·Emily S WillettRichard A Reinhardt
Apr 14, 2017·Journal of Applied Oral Science : Revista FOB·Bianca Fernanda Espósito SantosLeandro Araújo Fernandes
Jun 27, 2018·Pharmaceutical Research·Xiaobei WangDong Wang
Jun 24, 2017·Journal of Oral Science·Fatma Y KırzıoğluHikmet Orhan
Nov 11, 2018·Journal of Translational Medicine·Ae Ri KimYun-Jung Yoo
Sep 16, 2020·Journal of Applied Biomaterials & Functional Materials·Bingjiao ZhaoQiang Li
Apr 3, 2019·Mediators of Inflammation·Catherine PetitOlivier Huck
May 15, 2021·Advanced Healthcare Materials·Chunxia RenHongchen Sun

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