Effect of single doses of sodium valproate on serum phenytoin levels and protein binding in epileptic patients

Clinical Pharmacology and Therapeutics
A Monks, A Richens

Abstract

Our study underlines the importance of performing protein binding interaction studies in vivo. Predictions from in vitro studies may be misleading because they may not take into account the kinetics of the drug in the whole animal. Probably the most important clinical implication of these findings is that total serum phenytoin levels may fall when sodium valproate is added to therapy and this may lead to an increase in dose under the mistaken belief that the effect of the drug has been reduced. Since it is the bound and not the free drug which is reduced, phenytoin intoxication may result from this misguided action.

Citations

Sep 1, 1985·Epilepsia·A S Troupin, L M Shaw
Jan 1, 1990·The Journal of International Medical Research·F PisaniR Di Perri
Jul 1, 1985·Annals of Neurology·W H TheodoreH Kupferberg
May 1, 1985·Pharmacotherapy·E M Rimmer, A Richens
Jan 12, 1999·British Journal of Pharmacology·O E Della PaschoaM Danhof
May 1, 1993·Biopharmaceutics & Drug Disposition·M L Lai, J D Huang
Mar 1, 1981·Postgraduate Medical Journal·C J RobertsP A Dieppe
Feb 1, 1981·Epilepsia·K M KochR H Levy
Dec 13, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Amitava Dasgupta
Jul 1, 1984·British Journal of Clinical Pharmacology·L M TsanaclisA Richens
Aug 18, 2020·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Behrouz SeyfinejadAbolghasem Jouyban
Oct 1, 1982·Drug Intelligence & Clinical Pharmacy·P A Keys
Jun 1, 1982·Epilepsia·I H PatelL M Ojemann
Apr 1, 1982·British Journal of Clinical Pharmacology·S Dhillon, A Richens

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