Effect of single-session dual-tDCS before physical therapy on lower-limb performance in sub-acute stroke patients: A randomized sham-controlled crossover study

Annals of Physical and Rehabilitation Medicine
Wanalee KlomjaiVimonwan Hiengkaew

Abstract

Anodal stimulation increases cortical excitably, whereas cathodal stimulation decreases cortical excitability. Dual transcranial direct current stimulation (tDCS; anodal over the lesioned hemisphere, cathodal over the non-lesioned hemisphere) was found to enhance motor learning. The corresponding tDCS-induced changes were reported to reduce the inhibition exerted by the unaffected hemisphere on the affected hemisphere and restore the normal balance of the interhemispheric inhibition. Most studies were devoted to the possible modification of upper-limb motor function after tDCS; however, almost no study has demonstrated its effects on lower-limb function and gait, which are also commonly disordered in stroke patients with motor deficits. In this randomized sham-controlled crossover study, we included 19 patients with sub-acute stroke. Participants were randomly allocated to receive real or sham dual-tDCS followed by conventional physical therapy with an intervention interval of at least 1 week. Dual-tDCS was applied over the lower-limb M1 at 2-mA intensity for 20min. Lower-limb performance was assessed by the Timed Up and Go (TUG) and Five-Times-Sit-To-Stand (FTSTS) tests and muscle strength was assessed by peak knee torque of e...Continue Reading

Citations

May 13, 2020·Disability and Rehabilitation·Stephen BornheimJean-François Kaux
Jul 19, 2019·Journal of Neuroengineering and Rehabilitation·Isadora Santos FerreiraFelipe Fregni
Jul 1, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Jamie YoungMary P Galea
Jul 23, 2020·Frontiers in Neurology·Echezona Nelson Dominic EkechukwuMayowa Ojo Owolabi
Jul 18, 2020·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Hui-Hsun TienHen-Yu Lien
Nov 8, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Antonino NaroRocco Salvatore Calabrò
Mar 25, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Luana Billeri, Antonino Naro
Jul 28, 2020·The International Journal of Neuropsychopharmacology·Felipe FregniUNKNOWN Neuromodulation Center Working Group

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