PMID: 3698993Jan 1, 1986Paper

Effect of sleep deprivation on cholesterol metabolism and triglyceridaemia in male volunteers

European Journal of Applied Physiology and Occupational Physiology
K VondraJ Kopecká


The effect of 5-day sleep deprivation (SD) on cholesterol metabolism, together with triglyceridaemia, was studied in seven healthy male volunteers. A 3-day control period was followed by 5 days (120 h) complete SD and 4 days recovery. Blood was collected at 9 a.m. and at 9 p.m. Vastus lateralis muscle biopsy was performed during the control period, on the 5th day of SD, and on day 3 of recovery. The value of muscle cholesterol was related to the non-collagen protein content. The plasma triglycerides (TG) varied in a circadian biorhythm, the amplitude of which declined gradually during SD. The morning triglyceridaemia was significantly decreased on days 3-5 of SD (35%-79% of initial values). On days 4 and 5 of SD, plasma cholesterol fell significantly to 78% and 88% of control values, respectively. The ratio of its esterified to unesterified fractions remained unchanged throughout SD. Basal activity of lecithin cholesterol acyltransferase (LCAT) showed no diurnal biorhythm; on the last 2 days of SD, LCAT activity fell significantly to 71%-80%. In contrast, the decrease in fractional esterification rate (FER) was insignificant. In the vastus lateralis muscle, total cholesterol (TC) was decreased by 40% at the end of SD, the reduc...Continue Reading


Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·J FérézouC Rathat
Dec 17, 2008·Nutrition Research Reviews·Cibele Aparecida CrispimMarco Túlio de Mello
Nov 1, 1992·European Journal of Clinical Investigation·Y IlanP Lavie
Dec 1, 1990·Journal of the American College of Nutrition·B L SmoakP A Deuster
Sep 6, 2019·Journal of Lipid Research·Kelly M NessOrfeu M Buxton
Sep 1, 1995·The American Journal of Physiology·L K CellaD A Schoeller

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