PMID: 2496434Jan 1, 1989Paper

Effect of smoke-free cigarettes on 24 h cigarette withdrawal: a double-blind placebo-controlled study

Psychopharmacology
P HajekC Feyerabend

Abstract

In a double-blind randomised trial, 40 cigarette smokers used either nicotine-containing or placebo smoke-free cigarettes during 24 h abstinence from smoking. Subjects in the nicotine group experienced smaller increases in irritability and difficulty concentrating and fewer urges to smoke than those who received placebo. Nicotine smoke-free cigarettes were rated as more satisfying, more helpful and more effective in relieving craving than placebo. After 24 h use nicotine smoke-free cigarettes provided average blood nicotine levels of 6.3 ng/ml, i.e., 29.2% of smoking levels. The most frequent side effects were irritation of the throat and coughing. Overall, side effects were rated as not serious. Although the smoke-free cigarette in its present form is not very efficient in delivering nicotine, it was effective in alleviating initial tobacco withdrawal. It is possible that by providing both nicotine and "behavioural" replacement it may be particularly useful in the first stages of stopping smoking. The product is worth further investigation.

References

Feb 1, 1979·The Journal of Pharmacy and Pharmacology·C Feyerabend, M A Russell
Sep 1, 1987·British Journal of Addiction·M J JarvisC Feyerabend
Jun 19, 1987·JAMA : the Journal of the American Medical Association·M A RussellC Feyerabend
Nov 1, 1986·American Journal of Public Health·D W SepkovicN J Haley
Oct 1, 1985·Clinical Pharmacology and Therapeutics·J E RoseM E Jarvik
Apr 5, 1980·British Medical Journal·M A RussellC Feyerabend
Aug 16, 1980·British Medical Journal·M J JarvisY Saloojee

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Citations

May 1, 1997·Pharmacology, Biochemistry, and Behavior·J GrossM L Stitzer
Jun 8, 2006·Experimental and Clinical Psychopharmacology·Sarah E EvansThomas Eissenberg
May 21, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Simon ThornleyRobyn Whittaker
Nov 1, 1994·Addiction·P Hajek
Jun 6, 2009·International Journal of Clinical Practice·K Látalová
Jan 1, 1996·Annual Review of Medicine·J E Rose
Oct 19, 2001·Clinical Pharmacokinetics·N G SchneiderE Lunell
Jun 1, 1989·British Journal of Addiction·P Hajek
Aug 2, 2014·Therapeutic Advances in Drug Safety·Konstantinos E Farsalinos, Riccardo Polosa
Aug 2, 2018·Addiction·Peter HajekUNKNOWN The Preloading Investigators

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