Effect of smoke inhalation on viscoelastic properties and ventilation distribution in sheep

Journal of Applied Physiology
Thomas RiedelAndreas Schibler

Abstract

Smoke inhalation injuries are the leading cause of mortality from burn injury. Airway obstruction due to mucus plugging and bronchoconstriction can cause severe ventilation inhomogeneity and worsen hypoxia. Studies describing changes of viscoelastic characteristics of the lung after smoke inhalation are missing. We present results of a new smoke inhalation device in sheep and describe pathophysiological changes after smoke exposure. Fifteen female Merino ewes were anesthetized and intubated. Baseline data using electrical impedance tomography and multiple-breath inert-gas washout were obtained by measuring ventilation distribution, functional residual capacity, lung clearance index, dynamic compliance, and stress index. Ten sheep were exposed to standardized cotton smoke insufflations and five sheep to sham smoke insufflations. Measured carboxyhemoglobin before inhalation was 3.87 +/- 0.28% and 5 min after smoke was 61.5 +/- 2.1%, range 50-69.4% (P < 0.001). Two hours after smoke functional residual capacity decreased from 1,773 +/- 226 to 1,006 +/- 129 ml and lung clearance index increased from 10.4 +/- 0.4 to 14.2 +/- 0.9. Dynamic compliance decreased from 56.6 +/- 5.5 to 32.8 +/- 3.2 ml/cmH(2)O. Stress index increased from 0...Continue Reading

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Citations

Sep 30, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Pei-ming HuangCharles A Hales
Jan 27, 2011·Critical Care : the Official Journal of the Critical Care Forum·Caroline A GrantAndreas Schibler
Jul 6, 2013·Journal of Critical Care·Kiran ShekarJohn F Fraser
Sep 11, 2010·The Journal of Surgical Research·Cherry Ballard-CroftJoseph B Zwischenberger
Feb 5, 2008·Burns : Journal of the International Society for Burn Injuries·Ingrid SteinvallFolke Sjoberg
Sep 3, 2013·Vox Sanguinis·G SimonovaY L Fung
Aug 6, 2011·Respiratory Physiology & Neurobiology·Mariana Barcellos AvilaWalter Araujo Zin
Mar 7, 2015·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Charles I McDonaldJohn F Fraser
Nov 7, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Margaret R PassmoreJohn F Fraser
Dec 26, 2018·Expert Opinion on Drug Metabolism & Toxicology·Vesa ChengKiran Shekar
Sep 10, 2009·Physiological Measurement·Daniel RooneyAndreas Schibler
Jul 22, 2015·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Rylan A HayesJohn F Fraser
May 18, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Barbara VogtInéz Frerichs
Jul 30, 2017·Critical Care : the Official Journal of the Critical Care Forum·Margaret R PassmoreJohn F Fraser

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