Effect of smoking habit on circulating adipokines in diabetic and non-diabetic subjects

Annals of Nutrition & Metabolism
Sana S Al MutairiNabila Abdella

Abstract

Despite the well-known inverse association between smoking and body weight, there have been conflicting reports on the association between smoking and adipokines such as leptin and adiponectin. To determine and compare whether tobacco smoking (cigarettes or sheesha) affects circulating levels of adiponectin and/or influences leptin and leptin receptor (sOb-R) concentrations and free leptin in diabetic and non-diabetic subjects. Fasting plasma adiponectin, leptin, sOb-R, glucose, insulin, and lipid profile were determined in 236 subjects grouped as control subjects (n = 53); non-diabetic cigarette smokers (n = 34), non-diabetic sheesha smokers (n = 38), diabetic nonsmokers (n = 75) and diabetic smokers (n = 36). Uni- and multivariate regression analyses were used to determine the associations of these variables with body mass index (BMI) and smoking. When compared to control subjects, smoking cigarettes or sheesha was associated with significantly higher glucose, insulin resistance, total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C) and lower serum leptin, sOb-R and free leptin. The effects of smoking on BMI, leptin and sOb-R were dose-dependent. Binary logistic regression analysis showed that smoking ...Continue Reading

Citations

Jul 14, 2010·European Journal of Medical Research·S Bergmann, R Siekmeier
Dec 4, 2012·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)· MutakinHiroshi Koyama
May 9, 2012·Trends in Endocrinology and Metabolism : TEM·Jesse Oliver TweedTheodore C Friedman
Feb 17, 2009·Atherosclerosis·Stamatis P EfstathiouTheodore D Mountokalakis
Oct 23, 2009·Journal of Applied Toxicology : JAT·Sandra StasenkoVesna Kusec
Feb 3, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·D R FariasG Kac
Dec 7, 2016·Annals of Saudi Medicine·Muhammad Zulhusni SuhaimiHarmy Mohamed Yusoff
Dec 14, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Luqi ShenChangwei Li
Sep 9, 2009·Upsala Journal of Medical Sciences·Bayram KocMustafa Sahin
Nov 7, 2020·Frontiers in Endocrinology·Julia Bandres-MerizGernot Desoye

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.