Effect of sodium and potassium supplementation on vascular and endothelial function: a randomized controlled trial

The American Journal of Clinical Nutrition
Natalie BlanchJennifer B Keogh

Abstract

It is known that increased potassium and reduced sodium intakes can improve postprandial endothelial function. However, the effect of increasing potassium in the presence of high sodium in the postprandial state is not known. We aimed to determine the effect of high potassium and high sodium on postprandial endothelial function as assessed by using flow-mediated dilatation (FMD) and arterial compliance as assessed by using pulse wave velocity (PWV) and central augmentation index (AIx). Thirty-nine healthy, normotensive volunteers [21 women and 18 men; mean ± SD age: 37 ± 15 y; BMI (in kg/m(2)): 23.0 ± 2.8] received a meal with 3 mmol K and 65 mmol Na (low-potassium, high-sodium meal (LKHN)], a meal with 38 mmol K and 65 mmol Na [high-potassium, high-sodium meal (HKHN)], and a control meal with 3 mmol K and 6 mmol Na (low-potassium, low-sodium meal) on 3 separate occasions in a randomized crossover trial. Brachial artery FMD, carotid-femoral PWV, central AIx, and blood pressure (BP) were measured while participants were fasting and at 30, 60, 90, and 120 min after meals. Compared with the LKHN, the addition of potassium (HKHN) significantly attenuated the postmeal decrease in FMD (P-meal by time interaction < 0.05). FMD was sign...Continue Reading

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Citations

Nov 29, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·P Clifton
Mar 3, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Weizhong HanMin Li
Nov 8, 2017·Public Health Nutrition·Kacie M DickinsonMichelle Miller
Jun 5, 2020·The Journal of Clinical Hypertension·Giovanna ValentinoMónica Acevedo
Jun 6, 2018·International Journal of Environmental Research and Public Health·Michelle L HeadlandJennifer B Keogh
Jun 27, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Kamila U MigdalWilliam B Farquhar
Oct 11, 2020·Physiological Reports·Kamila U MigdalWilliam B Farquhar
Jun 3, 2021·International Journal of Environmental Research and Public Health·Caitríona MurphyPeter M Clifton

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