PMID: 6989479Apr 1, 1980Paper

Effect of sodium fluoride, calcium carbonate, and vitamin D on the skeleton in multiple myeloma

Cancer
R A Kyle, J Jowsey

Abstract

Fifteen patients with multiple myeloma were treated with sodium fluoride (50 mg twice daily) plus calcium carbonate (1 g four times daily) or with the same fluoride-calcium dosage plus vitamin D (50,000 U twice weekly). All patients had increased bone formation, as shown by microradiography and videodensitometry. Ten patients had osteosclerosis demonstrated by roentgenograms. Compressive strength of the vertebral bodies was greater among those who received fluoride-calcium than among controls. Densitometry studies were not helpful. Side-effects were minimal and consisted of nausea and fibrositic symptoms. Hypocalcemia occurred less frequently in patients who received vitamin D along with fluoride-calcium. Administration of sodium fluoride and calcium carbonate produces an increase in bone mass and is a useful adjunct treatment for patients with multiple myeloma.

References

Jun 15, 1972·The New England Journal of Medicine·J B HarleyO Glidewell
Jul 1, 1972·The American Journal of Medicine·J JowseyD L Hoffmann
Feb 1, 1968·Archives of Internal Medicine·P P CarboneF Mullins
Jun 1, 1968·The Journal of Clinical Endocrinology and Metabolism·J JowseyF W Reutter
Oct 1, 1969·The American Journal of Medicine·S S JollyO C Mathur
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Nov 7, 1966·JAMA : the Journal of the American Medical Association·P Cohen
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Citations

Feb 1, 1985·Postgraduate Medical Journal·D E Bergsagel
Jan 1, 1982·Metabolic Bone Disease & Related Research·P D DelmasP J Meunier
Jul 1, 1985·Scandinavian Journal of Haematology·R A Kyle

Related Concepts

Bone Diseases
Vaterite
Clinical Trials
Double-Blind Method
Polychemotherapy
Fluorides
Multiple Myeloma
Placebos
Fluoristat
Vitamin D

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