PMID: 2096385Nov 1, 1990Paper

Effect of sodium fluoride on growth of human diploid cells in culture

Pharmacology & Toxicology
A OguroK Horii

Abstract

Cytotoxicity of sodium fluoride (NaF) on human diploid cells in exponential growth was investigated using a) Flow 1000 cells, passage No. 13, obtained from skin and muscle tissues of male black foetus, b) IMR-90 cells, passage No. 22, derived from lung tissue of female Caucasian foetus and c) primary fibroblast-like cell cultures from 5 Japanese whole foetuses. Diploid cells did not survive at 20 p.p.m. of ionic fluoride (F-) concentration. However, the cells were capable of proliferation with no significant impairment of growth up to 0.2 p.p.m. F-, a level which is much higher than the plasma concentration in human subjects from areas with highly fluoridated water. The growth of the cells was markedly affected by F- concentrations greater than 2 p.p.m.

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Citations

Jan 1, 1994·Archives of Environmental Contamination and Toxicology·A M Khalil, A A Da'dara
Mar 1, 2002·Environmental Toxicology and Pharmacology·Je-Seon SongJeong Hee Kim
Feb 15, 2001·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Y C Chang, M Y Chou
Aug 8, 2014·Environmental Science & Technology·Mingzhe FuSong Hua
Jan 13, 2015·Operative Dentistry·G B EyüboğluM Ertürk
Feb 21, 2019·Acta Odontologica Scandinavica·Antonija TadinDavor Zeljezic
May 30, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R L Stariha, S U Kim
Jan 7, 2021·Biological Trace Element Research·K L VandanaRajendra Desai
Jul 30, 2019·Journal of Current Glaucoma Practice·Jessica OlayanjuDavid Fleischman

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