Effect of sodium houttuyfonate on inhibiting ventricular remodeling induced by abdominal aortic banding in rats

Canadian Journal of Physiology and Pharmacology
Jian Ping GaoXiang Li

Abstract

Ventricular remodeling is an independent risk factor for many cardiovascular events. Inhibiting ventricular remodeling early may be an effective way to postpone heart failure for patients with cardiovascular illness. The study was designed to examine the effect of sodium houttuyfonate on ventricular remodeling induced by pressure overload in rats, as well as to explore the mechanisms involved. The model rats in which ventricular remodeling was induced abdominal aortic banding (AAB) were randomly divided into 4 groups: AAB control, AAB plus captopril (40 mg/kg), AAB plus low dose of sodium houttuyfonate (50 mg/kg), and AAB plus high dose of sodium houttuyfonate (100 mg/kg). One month after operation, hemodynamic parameters, heart mass indexes, size of cardiomyocytes, myocardial collagen volume, angiotensin II content in ventricular tissue, and serum concentrations of aldosterone and tumor necrosis factor (TNF)-alpha were evaluated. Sodium houttuyfonate significantly reduced heart mass indexes, the size of cardiomyocytes, and the myocardial collagen volume and decreased the levels of angiotensin II, aldosterone, and TNF-alpha. At the high dose, it decreased blood pressure and heart rate. In conclusion, sodium houttuyfonate attenu...Continue Reading

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Citations

Jan 6, 2016·Life Sciences·Maryam RameshradRohollah Fadaei Fouladi
Mar 26, 2014·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Jing ShaoJinliang Huang
Mar 16, 2021·Frontiers in Pharmacology·Yun-Hui ShenJian Gao

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