Abstract
We have investigated the action of sodium nitrite on the growth and morphologic changes of T. vaginalis and on the treatment of subcutaneous abscess by trichomonad in mice. Sodium nitrite inhibited the growth of metronidazole-sensitive KT9 isolate and metronidazole-resistant CDC85 strain of T. vaginalis as concentration of 6 mM and 10 mM, respectively. Intraperitoneal injection of sodium nitrite (70 micrograms, 100 micrograms, 130 micrograms/g body weight) did not reduce the size of abscess produced by subcutaneous inoculation of T. vaginalis in mice. T. vaginalis, treated with sodium nitrite at concentration giving about 50% inhibition of growth, showed fissures, many vacuoles and electron-translucent zone in the cytoplasm by transmission electron microscopy. In the case of CDC85 treated with 9 mM sodium nitrite, hydrogenosomal matrical change, destruction of hydrogenosomal membrane, autophagic vacuoles, disappearance of Golgi complex and polysome were notably observed. With above results, it is assumed that sodium nitrite inhibits the growth of metronidazole-sensitive and--resistant strains of T. vaginalis and induces the morphological changes of T. vaginalis although it does not affect in reducing of abscess size by T. vagin...Continue Reading
References
Dec 1, 1977·Experimental Parasitology·G CarosiA Dei Cas
Apr 1, 1978·The British Journal of Venereal Diseases·J G MeingassnerH Mieth
Feb 1, 1979·Antimicrobial Agents and Chemotherapy·J G Meingassner, J Thurner
Jun 13, 1975·Science·M S LegatorM Stoeckel
Sep 16, 1975·Biochemical and Biophysical Research Communications·H S Rosenkranz, W T Speck
Apr 1, 1992·Journal of Clinical Pharmacology·S I BaskinE W Nealley
Sep 1, 1991·Infection and Immunity·K A RockettI A Clark
Jul 1, 1991·Infection and Immunity·J A Alspaugh, D L Granger
Oct 1, 1990·Journal of General Microbiology·M J PayneR Cammack
Oct 1, 1990·Journal of General Microbiology·M J PayneR Cammack
Jan 1, 1988·Sexually Transmitted Diseases·M MüllerT E Gorrell
Jan 1, 1985·Molecular and Biochemical Parasitology·N YarlettM Müller
Sep 12, 1981·Lancet·S A Waitkins, D J Thomas
Dec 1, 1982·The British Journal of Venereal Diseases·J KuldaE Kunzová
Dec 1, 1980·American Journal of Obstetrics and Gynecology·M MüllerW J Ledger
Aug 1, 1995·FEMS Microbiology Letters·J S Ryu, D Lloyd
May 1, 1993·Parasitology Today·P J Johnson
Citations
May 3, 2001·Enfermedades infecciosas y microbiología clínica·F VázquezV Palacio
Jul 1, 2006·The Korean Journal of Parasitology·Jae-Sook Ryu, Duk-Young Min
Oct 23, 1997·The Korean Journal of Parasitology·G C ParkD Y Min
Oct 2, 1998·The Korean Journal of Parasitology·J S RyuY H Cho
Dec 30, 1998·The Korean Journal of Parasitology·J S RyuD Y Min