PMID: 8970807Sep 15, 1996Paper

Effect of sodium nitroprusside on compound action potential thresholds in the gerbil cochlea

Hearing Research
C G DaisH C Pillsbury

Abstract

The presence of active nitric oxide synthase (NOS) in the spiral ganglion cells of the cochlea suggests that the neuromodulator nitric oxide (NO) may play a role in hearing. This study investigated the effects of sodium nitroprusside (SNP), an NO donor, upon cochlear function mediated through its activation of guanylate cyclase. In gerbils, cochlear compound action potential (CAP) thresholds were recorded after cochlear perfusions of control and test solutions in four experimental groups. Perfusions were performed using the following: artificial perilymph solution (APS); the NO donor SNP; the guanylate cyclase inhibitor methylene blue (MB); and sodium dodecyl sulfate (SDS), which facilitates MB entrance into cells. SNP caused significant elevations of CAP thresholds from baseline (25 dB SPL +/- 1.54 dB to 64.3 dB SPL +/- 2.54 dB). SNP with MB also resulted in significant CAP threshold elevations (29.4 dB SPL +/- 4.27 dB to 38.1 dB SPL +/- 4.0 dB); however, these elevations were significantly lower than those seen in SNP perfusions without MB. Drilling perfusion holes and perfusion of APS, APS/SDS, and MB/SDS/APS solutions did not significantly affect CAP thresholds. These results suggest that the NO donor nitroprusside does aff...Continue Reading

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Citations

Dec 19, 2002·Otolaryngologic Clinics of North America·Michael M Paparella, Hamid R Djalilian
Apr 10, 2003·Hearing Research·Min-Jon LinShiann-Yann Lee
Feb 3, 1998·Hearing Research·R S RuanK H Yeoh
Jul 23, 1999·Hearing Research·O MichelK Addicks
Jun 22, 2002·Annals of the New York Academy of Sciences·Run-Sheng Ruan
Apr 21, 2001·Experimental Neurology·R S RuanK H Yeoh
Aug 17, 1999·Experimental Neurology·R S RuanK H Yeoh
Apr 25, 2008·Hearing Research·Mihir R PatelJiri Prazma
Aug 29, 2000·The Annals of Otology, Rhinology, and Laryngology·K TabuchiJ Kusakari
Sep 22, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·C J ZdanskiH C Pillsbury
Oct 22, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·N PaiV Carrasco
Nov 24, 1998·Brain Research·A HessO Michel

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