Aug 1, 1975

Effect of sodium oxybutyrate on regional blood circulation and on neural regulation of vascular tonus

Biulleten' eksperimental'noĭ biologii i meditsiny
E A Bendikov, T S Ganyshina


The effect of sodium hydroxybutyrate on the blood flow in the aorta, carotid, mesenteric and femoral arteries were studied on cats and dogs. The circulation was assessed by the electromagnetic and resistographic methods, in the anesthetized and nonanesthetized animals. The tonic activity was recorded in the sympathetic nerves and the EEG. Sodium hydroxybutrate was shown to decrease the sympathetic activity, resulting in the increase of the regional circulation and induced the EEG synchronization. The latter effect was more pronounced in the arotid arteries. It can be assumed that sodium hydroxybutyrate affects the nervous control of the blood vessels.

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Mentioned in this Paper

Blood Flow Velocity
Sympathetic Nervous System
Hydroxybutyric Acids
Diastolic Blood Pressure
Synaptic Transmission
Regional Blood Flow
Limb Structure
Pulmonary Vascular Resistance

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