PMID: 9654646Jul 9, 1998Paper

Effect of sodium restriction on urinary excretion of cortisol and its metabolites in humans

Steroids
S LewickaP Vecsei

Abstract

The adrenal gland is involved in the control of urinary sodium excretion mainly via the secretion of the mineralocorticoid aldosterone. Although under certain conditions glucocorticoid seem to be also involved in the regulation of sodium homeostasis, there are contradictory reports on the relationship between cortisol secretion and sodium intake. Given recent findings linking regulation of physiological activity of steroids to the activity of specific enzymatic pathways, we have examined changes in urinary excretion of cortisol and its metabolites in eight healthy volunteers on a low sodium diet. Urinary steroids were measured with specific radioimmunoassays after extraction and chromatography (F and E) or after dilution (THF and THE). Excretion of cortisol (124 +/-41 nmol/day) was significantly lower on Day 2 (86 +/- 27 nmol/day, p < 0.01) and Day 7 (85 +/- 25 nmol/day, p < 0.01) of sodium restriction. On the same samples calculated ratios of THF/F (55 +/- 15; 61 +/- 22; 68 +/- 21) and E/F (2.5 +/- 0.6; 2.8 +/- 1.4; 3.0 +/- 1.3) reflecting the activity of 5 beta-reductase and 11 beta-hydroxysteroid dehydrogenase, respectively, showed significant increases in the former on both Days 2 and 7 and for the latter only on Day 7. Thi...Continue Reading

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Citations

May 10, 2008·The British Journal of Nutrition·Susan J TorresAnthony Worsley
Mar 3, 2005·Medicine and Science in Sports and Exercise·Martin Fenske
Mar 17, 2006·Medicine and Science in Sports and Exercise·Martin Fenske
Nov 3, 2010·Metabolism: Clinical and Experimental·Rajesh GargGail K Adler
Mar 20, 2009·Clinical Biochemistry·Alicja KotłowskaPiotr Stepnowski
Jun 20, 2003·European Journal of Clinical Investigation·M N KerstensR P F Dullaart
Nov 16, 2017·Current Hypertension Reports·Matthew A Bailey
Jun 9, 2020·Clinical Endocrinology·Angela X ChenAnand Vaidya
Sep 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Michiel N KerstensRobin P F Dullaart

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