Effect of somatostatin on ion transport in the rat colon

The Journal of Clinical Investigation
K DharmsathaphornJ Dobbins

Abstract

The effect of somatostatin (SRIF) on ion transport was determined in the rat colon in vitro. SRIF produced a sustained decrease in the short circuit current (Isc) (-0.8 +/- 0.1 mueq/h x cm2) and increased net Cl absorption (0.9 +/- 0.3 mueq/h x cm2). The threshold effect of SRIF on Isc was observed at 6 nM. 10 microM serotonin decreased net Na absorption (-2.6 +/- 0.4 mueq/h x cm2), net Cl absorption (-3.6 +/- 0.5 mueq/h x cm2) and increased Isc (0.7 +/- 0.1 mueq/h x cm2); these changes were totally blocked by 0.1 microM SRIF. SRIF completely blocked net Cl secretion induced by 10 mM theophylline (-2.5 +/- 0.7 to +4.1 +/- 2.0 muq/h x cm2) and partially blocked theophylline-induced inhibition of net Na absorption (0.7 +/- 0.5 to 2.1 +/- 0.4 mueq/h x cm2). SRIF also blocked prostaglandin E1 (PGE1) induced increase in potential difference and Isc (P < 0.001). Mucosal cyclic AMP levels were increased by theophylline and PGE1 but not by serotonin. SRIF had no effect on basal or theophylline- and PGE1-stimulated cyclic AMP levels. These results indicate that SRIF blocks both cyclic AMP and noncyclic AMP mediated changes in ion secretion and suggest that SRIF is acting at a step in the secretory process beyond the formation of cyclic ...Continue Reading

References

Jan 1, 1978·Molecular and Cellular Endocrinology·J G Schofield, R J Bicknell
May 1, 1977·Current Problems in Cancer·R M Jager, H C Polk
Dec 1, 1975·The American Journal of Digestive Diseases·M Donowitz, H J Binder
Jan 1, 1980·Annals of Internal Medicine·K DharmsathaphornJ Dobbins

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Citations

Jan 1, 1986·Pflügers Archiv : European journal of physiology·H Knauf, K Haag
Jun 15, 1984·Klinische Wochenschrift·A Lückhoff, M Horster
Sep 1, 1986·Veterinary Research Communications·L Ooms, A Degryse
Aug 10, 1990·European Journal of Pharmacology·J A FerrarH M Cox
Jan 1, 1988·Comparative Biochemistry and Physiology. A, Comparative Physiology·M P López-RuizE Arilla
Jul 1, 1981·Biochimica Et Biophysica Acta·F Reyl, M J Lewin
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M P López-RuizJ C Prieto
Jun 7, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·A SamsonA G Butt
Mar 1, 1994·Zentralblatt für Veterinärmedizin. Reihe A·M B HansenE Skadhauge
Jul 1, 1992·Acta Physiologica Scandinavica·A SjöqvistO Lundgren
Dec 1, 1984·Gut·D S Rampton, C J Hawkey
May 16, 2006·Digestive Diseases·Michael J G Farthing
Apr 1, 1983·The Journal of Clinical Investigation·L E RosenthalK Dharmsathaphorn
Sep 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·U M FarackK Loeschke
Mar 1, 1995·Diseases of the Colon and Rectum·S YamanerE Ademoğlu
Mar 1, 1988·Diseases of the Colon and Rectum·T R KochV L Go
Jan 1, 1984·Cell and Tissue Research·J R KeastM Costa
Apr 1, 1982·British Journal of Pharmacology·A W Cuthbert, H S Margolius
Jan 1, 1981·Annals of the New York Academy of Sciences·J W DobbinsH J Binder
Jul 1, 1984·British Journal of Pharmacology·A W CuthbertJ A Spayne
Nov 17, 1980·Biochemical and Biophysical Research Communications·J FreedmanJ W Dobbins
Apr 17, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Christina L GreenDerek M McKay
Dec 12, 2001·Alimentary Pharmacology & Therapeutics·A Szilagyi, I Shrier
Jul 1, 1989·Medicinal Research Reviews·W J KinnierC Kaiser
Aug 4, 2005·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Tomohisa FushimiShu-Ichi Ikeda

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