PMID: 6109626Aug 1, 1980Paper

Effect of somatostatin on plasma renin activity and blood pressure in patients with essential hypertension

Endocrinologia Japonica
Y IzumiM Hatano

Abstract

The effects of somatostatin on plasma renin activity (PRA) and blood pressure were evaluated in patients with essential hypertension (EH) and in normotensive subjects. All subjects examined were hospitalized and placed on a diet containing 7-8 g/day sodium chloride and received an intravenous infusion of somatostatin (500 microgram/20 ml of saline, for 60 min) in the basal condition. During somatostatin infusion, the mean blood pressure (MBP) remained unaffected in all patients with EH and the normotensive subjects, while the PRA decreased slightly in the EH group. When the patients with EH were classified according to their renin levels (low, normal and high), parallel significant decreases in MBP and PRA were found only in the high renin group during the somatostatin infusion. No significant change in MBP and PRA was observed in the other groups including the normotensive subjects. To assess the activity of synthetic somatostatin, the plasma levels of growth hormone (GH) and cyclic AMP were measured. These levels were lowered significantly during the infusion and the GH levels showed a rebound 15 min after cessation of the infusion. The cyclic AMP returned to the basal levels, but no rebound was observed. The above data indic...Continue Reading

Citations

Mar 1, 1989·Diabetes/metabolism Reviews·A H Kissebah, A N Peiris
Aug 1, 1989·Hypertension·G M ReavenB B Hoffmann
Aug 6, 1987·The New England Journal of Medicine·L Landsberg

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