PMID: 3390649Apr 1, 1988

Effect of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs

British Journal of Pharmacology
R M Tripathi, R Kaushal

Abstract

1. Effects of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs were studied. 2. Ventricular premature beats, ventricular fibrillation and cardiac arrest were induced in pentobarbitone-anaesthetized guinea-pigs by a slow intravenous infusion of ouabain. 3. Aspirin and indomethacin were found to accord a significant protection to the guinea-pigs against arrhythmias whereas ketoprofen was found to be ineffective. 4. It is concluded that the protective effect of aspirin and indomethacin may be due to inhibition of synthesis and release of thromboxane A2 from the myocardium.

References

Dec 22, 1979·Lancet·P C Elwood, P M Sweetnam
Dec 1, 1976·The Journal of Allergy and Clinical Immunology·J R Vane
May 1, 1986·Journal of Clinical Pharmacology·C A CampbellR A Kloner
Dec 1, 1972·The American Journal of Physiology·A G Flores, G W Sharp
Jun 23, 1971·Nature: New Biology·J B Smith, A L Willis
Jul 1, 1967·The Journal of Pathology and Bacteriology·B J Northover

Citations

Jun 18, 2005·Journal of Pharmacological and Toxicological Methods·Daniela S HauserGuido Hanauer
Oct 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·I KanzikH Zengil
Mar 11, 2005·Autonomic & Autacoid Pharmacology·A T Demiryürek, S Demiryürek
Jan 1, 1995·Nutrition Research Reviews·K R GardinerB J Rowlands

Related Concepts

Analgesics, Anti-Inflammatory
Cardiac Arrhythmia
Zorprin
Diastolic Blood Pressure
Cavia porcellus
Pulse Rate
Hemodynamics
Osmosin
Profenid
Ouabain

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.