Effect of Sophora flavescens Aiton extract on degranulation of mast cells and contact dermatitis induced by dinitrofluorobenzene in mice

Journal of Ethnopharmacology
Hyungwoo KimSu In Cho

Abstract

The dried root of Sophora flavescens Aiton (Sophorae radix, SR) has long been used in traditional medicine for the treatment of fever and swelling in eastern countries. The present study investigated the anti-allergic and anti-inflammatory effects of SR using 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis mouse model and in vitro using RBL-2H3 cells. In mice, the topical application of 10 mg/mL of SR effectively inhibited enlargement of ear thickness and weight induced by repeated painting with DNFB. Topical application of SR also inhibited hyperplasia, edema, spongiosis and infiltration of mononuclear cells in ear tissue. In addition, production levels of interferon-gamma and tumor necrosis factor-alpha were decreased by SR in vivo. Finally, the release of histamine and β-hexosaminidase, and migration were inhibited by treatment with SR. These data indicate the potential of SR in treating patients with allergic skin diseases and also suggest that related mechanisms are involved in anti-inflammatory action on the Th 1 skewing reaction and inhibition against recruitment and degranulation of mast cells.

References

Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A H Enk, S I Katz
Jan 1, 1985·Archives of Dermatological Research·A HatamochiH Ueki
Jan 1, 1983·The Annals of Otology, Rhinology, and Laryngology·K Watanabe, I Watanabe
Nov 1, 1980·The Journal of Experimental Medicine·P W AskenaseR K Gershon
Feb 2, 2000·Journal of Natural Products·M KuroyanagiT Hayashi
Jul 14, 2001·Fitoterapia·S S KangH P Kim
Jul 18, 2002·International Archives of Allergy and Immunology·Tetsuya KawanoShigeru Kohno
Dec 26, 2002·Annual Review of Immunology·Hannah J GouldLyn Smurthwaite
May 22, 2004·Journal of the American Academy of Dermatology·Daniel W ShawHoward I Maibach
Aug 26, 2004·Dermatologic Therapy·David E Cohen, Noushin Heidary
Dec 3, 2004·Dermatitis : Contact, Atopic, Occupational, Drug·Apra Sood, James S Taylor
Sep 15, 2005·The Journal of Allergy and Clinical Immunology·Ming-Chun WenXiu-Min Li
Aug 9, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Mary E Fedor, Arye Rubinstein
Sep 2, 2006·Biological & Pharmaceutical Bulletin·Xiang-Lan PiaoShao-Qing Cai
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Yoshiro Kobayashi
Dec 21, 2007·Clinical Reviews in Allergy & Immunology·Daniel NaviFu-Tong Liu
Jan 26, 2008·Planta medica·Wenying QuanKyeong-Man Kim
Aug 13, 2008·The Journal of Allergy and Clinical Immunology·David Broide
Oct 22, 2008·Bioorganic & Medicinal Chemistry Letters·Young Bae RyuKi Hun Park
Jan 3, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Myung Hee HongSeong-Gyu Ko
Dec 26, 2009·Journal of Ethnopharmacology·Jeong Ho JinHyun Pyo Kim
Oct 12, 2010·Biological & Pharmaceutical Bulletin·Tianyou LiuXueying Sun
Oct 27, 2011·BMC Complementary and Alternative Medicine·Chun-chao HanJianyou Guo
Feb 14, 2012·Inflammation·Chun-Chao Han, Yingzi Wang

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Citations

Aug 29, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jason Jingjie YuChuanjian Lu
Oct 10, 2014·Pharmacognosy Magazine·Hye-Yeon HanMi Heon Ryu
Feb 24, 2016·Journal of Ethnopharmacology·Faheema SiddiquiAhsana Dar Farooq
Sep 7, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Zih-Yi WunChian-Jiun Liou
Feb 27, 2016·The American Journal of Chinese Medicine·Zih-Ying LiChian-Jiun Liou
Aug 24, 2019·Critical Reviews in Food Science and Nutrition·Kexin WangZhenxing Li
Mar 3, 2017·Chinese Journal of Integrative Medicine·Youngchul JungHyungwoo Kim
May 10, 2018·Frontiers in Aging Neuroscience·Hee-Young KimSeungtae Kim
Nov 9, 2018·International Journal of Molecular Sciences·Ha-Kyoung KwonHye-Jin Park
Apr 6, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Ming LiLinfeng Li
Jul 3, 2021·Journal of Ethnopharmacology·Myong Hak RiXuejun Jin
Sep 9, 2021·Critical Reviews in Food Science and Nutrition·Tian YangZhongfu Wang
Sep 29, 2021·Immunopharmacology and Immunotoxicology·Deepa S MandlikSnehal S Patel

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