Effect of sorbitol on the phosphate adsorptive capacity of ferrihydrite suspensions

Pharmaceutical Development and Technology
S E GruenhagenS L Hem

Abstract

The purpose of this study was to stabilize the phosphate adsorptive capacity of aqueous suspensions of ferrihydrite, a potential phosphate binder. Ferrihydrite was precipitated by the addition of 1 N NaOH to 1 M FeCl3 until pH 8.0 was reached. The ferrihydrite suspension was divided into three portions and an amount of sorbitol was added to produce sorbitol concentrations of 0, 1, or 5% w/v, respectively. The phosphate adsorptive capacity and X-ray diffraction pattern were periodically determined during aging at room temperature. The phosphate adsorptive capacity of the ferrihydrite suspension containing 0% sorbitol decreased steadily from 0.012 mgP/mg to 0.007 mgP/mg during the 1-year aging period. In contrast, suspensions containing 1 or 5% sorbitol exhibited constant phosphate adsorptive capacities during this period. X-ray diffraction patterns revealed that ferrihydrite transformed to hematite and goethite during aging of the control suspension. The presence of 1 or 5% sorbitol prevented the transformation of ferrihydrite to more crystalline iron oxides. This study suggests that the phosphate adsorptive capacity of ferrihydrite suspensions can be stabilized by the incorporation of small amounts of sorbitol into the formulat...Continue Reading

References

Aug 1, 1976·Journal of Pharmaceutical Sciences·S L NailS L Hem
Apr 27, 1989·The New England Journal of Medicine·J W Coburn, I B Salusky
Oct 1, 1981·Journal of Pharmaceutical Sciences·D N ShahS L Hem

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Citations

Dec 4, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Mahmoud Loghman-Adham
May 23, 2014·Drugs·Dimitra NastouAlberto Ortiz

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