PMID: 6164772May 1, 1981Paper

Effect of soy protein, casein and trypsin inhibitor on cholesterol, bile acids and pancreatic enzymes in mice

The Journal of Nutrition
D M Roy, B O Schneeman

Abstract

Dietary vegetable proteins may lower plasma cholesterol compared to animal proteins. We considered the possibility that lower digestibility and the trypsin inhibitor (TI) content of plant proteins could lead to alterations in bile acid metabolism and exocrine pancreatic function mediating some of this change. Mice were fed cholesterolemic diets of different protein source and TI content: casein, soy protein isolate, or casein plus TI for 4 weeks. Plasma and liver cholesterol were measured; pancreata, intestinal contents and mucosal scrapes were collected for bile acid, trypsin, chymotrypsin, amylase, and lipase assays. The soy group had lower plasma cholesterol levels. Intestinal bile acids in this group were higher, suggesting a causal relationship (increased bile acid secretion leading to increased cholesterol catabolism). Conversely, liver cholesterol in this group was raised, reflecting a possible shift in body cholesterol pools. TI addition did not affect lipid metabolism, though it did affect pancreatic function: it led to increased pancreatic weight and depressed intestinal trypsin activity, but elevated chymotrypsin and amylase levels in pancreas and intestine and increased trypsin levels in the pancreas. Therefore, soy...Continue Reading

Citations

Jan 1, 1984·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·V KamalakannanD B Motlag
Mar 27, 2013·Journal of Animal Physiology and Animal Nutrition·P F Surai
Dec 8, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Atefehalsadat SeyedanZahurin Mohamed
Sep 1, 1985·Zeitschrift für Ernährungswissenschaft·K E ScholzC A Barth
Sep 1, 1985·The British Journal of Nutrition·C J Woodward, K K Carroll
Mar 15, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L H GarthoffM A Khan
Jun 1, 1985·Archiv für Tierernährung·W B SouffrantR Matkowitz

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