Effect of soybeans and sword beans on bone metabolism in a rat model of osteoporosis

Annals of Nutrition & Metabolism
Jae Soon Byun, Sang Sun Lee

Abstract

Soy isoflavones have been reported to prevent bone loss in rat models of osteoporosis. However, the effect of the natural soybeans that people consume in their diet needs to be explored. In the present study, we evaluated the effects of yellow and black soybeans (Glycine max), and sword beans (Canavalia gladiate) on bone mineral density (BMD), bone mineral content (BMC), and bone biomarkers in ovariectomized (OVX) rats. Seven-week-old female Sprague-Dawley rats were raised for 2 weeks on a calcium-free diet based on the American Institute of Nutrition (AIN)-93M diets. All the rats received OVX, were randomized to one of four groups, and given one of the diets supplemented with casein, yellow soybean, black soybean, and sword bean for 10 weeks. BMD, BMC, osteocalcin (OC; a bone formation biomarker), deoxypyridinoline (DPD; a bone resorption biomarker), and TNF-alpha (a bone resorption cytokine) were assessed. In the femur and lumbar spine, BMD and BMC were significantly higher in the various bean groups than in the casein group. Among the bean groups, femur and spine BMD were significantly higher in the yellow soybean and sword bean groups than in the black soybean group. Femur BMC was the highest in the yellow soybean group, an...Continue Reading

Citations

Apr 30, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Xiu Juan Ye, Tzi Bun Ng
Apr 1, 2010·Journal of Pharmacy & Bioallied Sciences·Nitin Bansal, Milind Parle
Jan 29, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mee Youn LeeChoong Hwan Lee
Jun 4, 2011·Nutrition Research·Sun Hee LeeYongsoon Park
Mar 30, 2016·Bioscience, Biotechnology, and Biochemistry·Kaho NishizawaYasuhiro Arii
Oct 5, 2016·Journal of Medicinal Food·Beomjeong KimWoojin Jun
May 5, 2017·Nutrients·Kumar Ganesan, Baojun Xu
Jun 15, 2013·Nutrition Research and Practice·Yongsoon ParkDeog-Yoon Kim
May 21, 2021·The Journal of Bone and Joint Surgery. American Volume·Jeff S KimballDuWayne A Carlson
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kinga Kazimierska, Urszula Kalinowska-Lis

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