Effect of specific amino acids on hepatic lipid metabolism in fructose-induced non-alcoholic fatty liver disease

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Prasanthi JegatheesanJean-Pascal De-Bandt

Abstract

Fructose diets have been shown to induce insulin resistance and to alter liver metabolism and gut barrier function, ultimately leading to non-alcoholic fatty liver disease. Citrulline, Glutamine and Arginine may improve insulin sensitivity and have beneficial effects on gut trophicity. Our aim was to evaluate their effects on liver and gut functions in a rat model of fructose-induced non-alcoholic fatty liver disease. Male Sprague-Dawley rats (n = 58) received a 4-week fructose (60%) diet or standard chow with or without Citrulline (0.15 g/d) or an isomolar amount of Arginine or Glutamine. All diets were made isonitrogenous by addition of non-essential amino acids. At week 4, nutritional and metabolic status (plasma glucose, insulin, cholesterol, triglycerides and amino acids, net intestinal absorption) was determined; steatosis (hepatic triglycerides content, histological examination) and hepatic function (plasma aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, bilirubin) were assessed; and gut barrier integrity (myeloperoxidase activity, portal endotoxemia, tight junction protein expression and localization) and intestinal and hepatic inflammation were evaluated. We also assessed diets effects on ca...Continue Reading

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Citations

Mar 10, 2017·Nutrients·Prasanthi Jegatheesan, Jean-Pascal De Bandt
May 21, 2016·The British Journal of Nutrition·Prasanthi JegatheesanJean-Pascal De Bandt
Aug 25, 2019·Nutrients·Marja-Riitta TaskinenJan Borén
Mar 29, 2020·Biomolecules·Brittany DewdneyLionel Hebbard
Jun 6, 2020·International Journal of Food Sciences and Nutrition·Christine BrüttingGabriele I Stangl
Jul 6, 2016·Current Opinion in Clinical Nutrition and Metabolic Care·Prasanthi Jegatheesan, Jean-Pascal De Bandt
Jan 1, 2019·Current Pharmacology Reports·Rachel GolonkaMatam Vijay-Kumar
Oct 12, 2018·European Journal of Nutrition·Katherine J P SchwengerJohane P Allard
Oct 28, 2019·International Journal of Molecular Sciences·Simone PernaMariangela Rondanelli
Jul 3, 2018·Journal of Nutritional Science and Vitaminology·Tomonori SatoTakashi Nagasawa
Feb 10, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Weifang Huang, Desong Kong
Jan 26, 2021·JHEP Reports : Innovation in Hepatology·Emma L ShepherdPatricia F Lalor
Feb 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mengyao ZhaoLiming Zhao
May 18, 2021·Planta medica·Kasimu Ghandi IbrahimMustapha Umar Imam

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