PMID: 6166337Mar 1, 1981Paper

Effect of specific placental proteins--trophoblastic beta 1-glycoprotein chorionic alpha 1-microglobulin--on the proliferation of lymphocytes and malignant fibroblasts in vitro

Biulleten' eksperimental'noĭ biologii i meditsiny
Iu K GorlinaIu S Tamarinov

Abstract

A study was made of the action of trophoblastic beta 1-glycoprotein (TBG) and chorionic alpha 1-microglobulin (CAG1) on proliferation of malignant fibroblasts (transplanted L line) and on phytohemagglutinin-stimulated lymphocytes. TBG depressed proliferation of the stimulated lymphocytes and transformed fibroblasts (according to 3H-thymidine incorporation). A dose-response dependence was ascertained. CAG1 did not affect cell division. The inhibitory effect of TBG was seen to be reversed or decreased provided the lymphocyte culture was supplemented with CAG1. The decreased inhibitory effect of TBG in the presence of CAG1 was also noted in the L cell culture. It is likely that in vivo protection of intensely proliferating fetal tissues or tumor from the inhibitors is effected just in this way since placental proteins are synthesized both by embryonic and tumorous cells.

References

Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S Yachnin
Oct 15, 1974·International Journal of Cancer. Journal International Du Cancer·Y S TatarinovD M Falaleeva
Jan 1, 1973·Gynecologic Investigation·F TeasdaleM A Naughton

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