Effect of speed of rewarming and administration of anti-inflammatory or anti-oxidant agents on acute lung injury in an intestinal ischemia model treated with therapeutic hypothermia

Resuscitation
Kyuseok KimAdam J Singer

Abstract

Acute lung injury (ALI) develops in various clinical situations and is associated with high morbidity and mortality and therapeutic hypothermia (HT) has been studied to attenuate the ALI. However, the optimal method of rewarming has not been determined. We determined the effect of speed of rewarming and the administration of anti-inflammatory or anti-oxidant agents on ALI in an intestinal ischemia and reperfusion (I/R) model treated with HT. A Sprague-Dawley rat model of intestine ischemia and reperfusion was used. Two parallel animal experiments were conducted. In the survival study, rats (n=5 per group) underwent normothermic intestinal ischemia (60min, 36-38 degrees C) and then randomized into 7 groups with reperfusion: normothermia (NT), HT without rewarming (30-32 degrees C, HT), 2h HT+rewarming for 1h (RW1), 2h HT+rewarming for 2h (RW2), RW1+N-acetyl cysteine (RW-NAC), RW1+ethylpyruvate (RW-EP), and RW1+dexamethasone (RW+Dexa). In the second experiment, we investigated the histological and biochemical effects on the lung 4h after reperfusion (n=8 per group). The survival rate was lowest after NT. The HT, RW2, and RW-Dexa groups survived longer than the RW1, RW-NAC, and RW-EP groups. ALI scores were lower in the HT, RW2, a...Continue Reading

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Citations

Aug 14, 2012·The Journal of Surgical Research·Karen Ruggeri SaadEdna Frasson de Souza Montero
Apr 7, 2012·Mediators of Inflammation·Michael FrinkFrank Hildebrand
Mar 1, 2011·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Adam J SingerThomas Zimmerman
Jun 8, 2011·Cryobiology·Thomas MinorPatrik Efferz
Dec 31, 2014·Clinical and Experimental Emergency Medicine·You Hwan JoIn Soo Cho
Mar 28, 2017·Journal of Intensive Care Medicine·Adam J HayekAlejandro C Arroliga

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