Effect of sperm DNA fragmentation on pregnancy outcome depends on oocyte quality

Fertility and Sterility
Marcos MeseguerJose Luis Fernández

Abstract

To quantify the effect of sperm DNA fragmentation (SDF) on reproductive outcome by evaluating the most statistically significant bias factors using logistic regression. Prospective blind observational cohort study. University affiliated private IVF unit. Two hundred ten male partners of couples undergoing in vitro fertilization (IVF) or first intracytoplasmic sperm injection (ICSI) cycles with fresh or thawed sperm with the women's own or donated oocytes. None. SDF determined before and after swim-up (n=420), odds ratio calculated of the effect of an increase of one unit of SDF on pregnancy, and stratified regression analysis performed to evaluate the confusion effect of oocyte quality, sperm origin, and the fertilization procedure. The effect of SDF on pregnancy was not affected by sperm origin (fresh or thawed) or fertilization procedure when measured both before and after swim-up. When oocytes from infertile patients were employed, SDF had a statistically significant negative impact on chance of pregnancy. For every 10% increase in SDF, the probability of not achieving pregnancy increased by 1.31. When donated oocytes were employed, SDF did not have a statistically significant effect. The effect of SDF on the probability of ...Continue Reading

References

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Citations

Oct 12, 2012·Journal of Assisted Reproduction and Genetics·Amanda Souza SettiEdson Borges
Oct 10, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A S SettiE Borges
Mar 4, 2014·Reproductive Biomedicine Online·Jesús AguilarMarcos Meseguer
Mar 4, 2014·Reproductive Biomedicine Online·Xavier VendrellMiguel Ruiz-Jorro
Jul 5, 2011·Asian Journal of Andrology·María EncisoJaime Gosálvez
Aug 11, 2011·Human Reproduction·Marcos MeseguerJose Remohí
Dec 19, 2015·Systems Biology in Reproductive Medicine·Tahereh HaghpanahHadi Azimi
Aug 21, 2013·Reproductive Biomedicine Online·Sheena E M LewisParviz Gharagozloo
Mar 19, 2013·Fertility and Sterility·Nicolás GarridoMarcos Meseguer
Jun 12, 2012·Reproductive Biomedicine Online·Rachel Brown, Joyce Harper
Jan 4, 2012·Andrologia·T EbnerL Parmegiani
Sep 12, 2015·Human Reproduction·Julian MarcosMarcos Meseguer
Jun 23, 2015·Reproductive Biomedicine Online·Sheena E M Lewis
May 1, 2015·Asian Journal of Andrology·Sheena E M Lewis, Kishlay Kumar
Aug 21, 2013·Free Radical Biology & Medicine·Anais NoblancAyhan Kocer
Jun 19, 2018·Journal of Developmental Origins of Health and Disease·M BourdonG Jolivet
Jan 30, 2018·Clinical and Experimental Reproductive Medicine·Hwa Young ChoiByung Chul Jee
Mar 5, 2016·Proceedings. Biological Sciences·Javier delBarco-TrilloEduardo R S Roldan

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