Effect of spinal cord lesions on forelimb target-reaching and on visually guided switching of target-reaching in the cat

Neuroscience Research
L G PetterssonB Tantisira

Abstract

Cats were trained to reach to an illuminated tube placed horizontally at shoulder level and retrieve food with the forepaw. The trajectory of an infrared light emitting diode, taped to the wrist dorsum, was recorded with a SELSPOT-like recording system. Movement paths and velocity profiles were compared before and after lesions: (1) in dorsal C5, transecting cortico- and rubrospinal pathways to the forelimb segments so that the cats could only use the C3-C4 propriospinal neurones (PNs) to command reaching, (2) in the ventral part of the lateral funicle in C5, transecting the axons of C3-C4 PNs so that the cats had to use circuitry in the forelimb segments to command reaching. Comparison of trajectories and velocity profiles before and after lesion 1 did not reveal any major qualitative change. After lesion 2, the last third of the movement was fragmented with separate lifting and protraction. Switching of target-reaching occurred when illumination was shifted to another tube during the ongoing movement. The switching latency measured from the time of illumination shift to the earliest change in movement trajectory had a minimal value of 50-60 ms. Short latencies were present after lesion 1 as well as lesion 2 which suggest that...Continue Reading

References

Oct 13, 1978·Experimental Brain Research·C Ghez, D Vicario
Oct 7, 1977·Brain Research·N Berman, E G Jones
Feb 1, 1976·The Journal of Physiology·J BakerJ Stein
Nov 15, 1987·The Journal of Comparative Neurology·M L McCurdyA R Gibson
Dec 1, 1987·The Journal of Physiology·D E Marple-Horvat, J F Stein
Jan 1, 1972·Experimental Brain Research·F BaldisseraM Udo
Jan 1, 1967·Experimental Brain Research·N TsukaharaK Kosaka
Nov 1, 1968·Acta Physiologica Scandinavica·S Landgren, H Silfvenius
Mar 10, 1984·The Journal of Comparative Neurology·F R RobinsonM Glickstein
Sep 1, 1983·The Journal of Physiology·D Ferster, S Lindström
Jan 17, 1983·Brain Research·E DietrichsP Brodal
Jan 1, 1995·Experimental Brain Research·J H MartinC Ghez
Oct 1, 1953·Journal of Neuropathology and Experimental Neurology·H KLUVER, E BARRERA
Mar 1, 1964·Experimental Neurology·R NYBERG-HANSEN

❮ Previous
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Citations

Apr 25, 2012·Experimental Brain Research·Tamar R MakinAlessandro Farnè
Jul 25, 2000·Trends in Neurosciences·A N Iwaniuk, I Q Whishaw
May 3, 2000·The European Journal of Neuroscience·A Boczek-FunckeM Illert
Oct 31, 2002·The European Journal of Neuroscience·L-G Pettersson, S Perfiliev
Aug 30, 2008·Journal of Neurotrauma·Scott K StackhouseJed S Shumsky
Oct 13, 1999·Proceedings. Biological Sciences·M A GrealyD N Lee
Mar 23, 1999·Neural Computation·A G BartoJ C Houk
Jun 21, 2008·Journal of Rehabilitation Research and Development·James V LynskeyRanu Jung
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·N WeidnerM H Tuszynski
Apr 25, 2012·Annual Review of Neuroscience·Bror Alstermark, Tadashi Isa
Jan 22, 2011·Neuropharmacology·Jamie R FlynnRobert J Callister
Jun 15, 2007·Journal of the Neurological Sciences·Florence M Bareyre
Aug 25, 2015·The European Journal of Neuroscience·Erik E StoutIrina N Beloozerova
Oct 19, 2004·Journal of Neuroscience Methods·Enrique Leo PortianskyGustavo Oscar Zuccolilli
Jun 11, 2015·The European Journal of Neuroscience·Daniel K WoodMelvyn A Goodale
Jul 21, 2012·Brain Research Bulletin·Lilian Fautrelle, François Bonnetblanc
Feb 12, 2008·Vision Research·Joo-Hyun Song, Ken Nakayama
Feb 18, 2004·Nature Neuroscience·Florence M BareyreMartin E Schwab
Jan 16, 2018·Disability and Rehabilitation. Assistive Technology·Hardeep SinghKristin E Musselman
Jan 28, 2021·Journal of Neurophysiology·Tsuyoshi NakajimaYukari Ohki

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