Effect of spinal monoaminergic neuronal system dysfunction on pain threshold in rats, and the analgesic effect of serotonin and norepinephrine reuptake inhibitors

Neuroscience Letters
Ryuta TamanoS Shinohara

Abstract

Dysfunction in the central serotonin (5-HT) and norepinephrine (NE) systems cause depression and pain. Descending spinal pain modulatory pathways are important in the analgesic mechanisms of antidepressants, particularly serotonin and norepinephrine reuptake inhibitors (SNRIs). While many non-clinical studies have demonstrated the roles of central monoaminergic systems in pain, there is little evidence to illuminate the direct contribution of spinal descending pain modulatory systems independently of depressive-like behavior. To examine the effects of dysfunction of spinal monoaminergic systems on pain sensitivity, we established a rat chronic pain model by administering lumbar-intrathecal reserpine to minimize its influence on brain. Lumbar-intrathecal reserpine evoked persistent mechanical hypersensitivity and corresponding reductions in spinal 5-HT and NE concentrations (from 767.2 to 241.6ng/g and from 455.9 to 41.7ng/g, respectively after reserpine 30nmol). Lumbar-intrathecal reserpine did not deplete brain monoamines or bring about depressive-like behavior in the forced swim test. Spinal monoamines depletion-induced pain sensitivity was ameliorated by lumbar-intrathecal administration of the SNRIs (duloxetine and milnacip...Continue Reading

References

Sep 26, 1997·The Clinical Journal of Pain·S Lautenbacher, G B Rollman
Nov 28, 2001·Journal of Neuroendocrinology·G Blackburn-Munro, R E Blackburn-Munro
May 30, 2002·Progress in Neurobiology·Mark J Millan
Jan 25, 2003·Journal of Clinical Psychopharmacology·Pierre V TranWilliam Z Potter
Nov 9, 2004·Trends in Pharmacological Sciences·Rie SuzukiAnthony H Dickenson
Jun 2, 2005·Pain·David J GoldsteinSmriti Iyengar
Jun 10, 2006·Trends in Pharmacological Sciences·Juan A MicóAlain Eschalier
Mar 20, 2008·Anesthesia and Analgesia·Takahiro SuzukiTakashi Mashimo
Apr 1, 2009·The Clinical Journal of Pain·Juliana Barcellos de SouzaSerge Marchand
Apr 27, 2010·Pain·Lars Arendt-NielsenThomas Graven-Nielsen
Jan 5, 2011·Pain Practice : the Official Journal of World Institute of Pain·Neil S RoskellTrong Kim Le
Mar 18, 2011·British Journal of Pharmacology·T Mixcoatl-Zecuatl, C G Jolivalt
Aug 10, 2012·Current Drug Therapy·Vladimir SkljarevskiJoachim Wernicke
Jan 9, 2013·The Journal of Pharmacology and Experimental Therapeutics·Liam J Burnham, Anthony H Dickenson
Mar 4, 2014·Experimental Brain Research·Antonio Rodríguez-GaztelumendiAlvaro Díaz

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Citations

Apr 9, 2016·Brain, Behavior, and Immunity·B KarshikoffJ Axelsson
Jan 12, 2017·Drugs·Erin T CareySawsan As-Sanie
Apr 8, 2017·The Journal of Physiology·Kirsty Bannister, A H Dickenson
Nov 2, 2018·Clinical Obstetrics and Gynecology·Sara R TillAndrew Schrepf
Dec 24, 2017·Bioscience Reports·Wei LuoWen-Ping Li
Jul 16, 2021·Pharmacology & Therapeutics·Evelyne Silva BrumSara Marchesan Oliveira

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