PMID: 2926575Apr 1, 1989

Effect of spironolactone-hydrochlorothiazide on lung function in infants with chronic bronchopulmonary dysplasia

The Journal of Pediatrics
B EngelhardtT A Hazinski

Abstract

To test the hypothesis that spironolactone-hydrochlorothiazide (Aldactazide) will improve urine output and lung function in infants with bronchopulmonary dysplasia, we studied 21 hospitalized, spontaneously breathing, oxygen-dependent infants with chronic bronchopulmonary dysplasia. Infants were randomly assigned to receive either a 1:1 mixture of spironolactone and hydrochlorothiazide orally (n = 12) (3 mg/kg/day of both compounds) or no treatment (n = 9) for 6 to 8 days each. Dynamic lung compliance, total pulmonary resistance, and hemoglobin oxygen saturation were measured on the first and last days of each study period. Fluid intake and urine output were measured each day. Although the treatment significantly increased urine output, neither lung mechanics nor oxygenation were improved by the drug. The magnitude of the diuresis achieved with spironolactone-hydrochlorothiazide treatment was comparable to the diuresis achieved in a previous study of furosemide treatment (J Pediatr 1986:109;1034-9). Statistical analysis indicated that a type II error was an unlikely explanation for our failure to detect a beneficial effect. In three patients, doubling the oral dose did not improve lung mechanics or oxygenation. We speculate tha...Continue Reading

References

Apr 1, 1987·Pediatric Research·E M McCannJ P Brady
Feb 1, 1972·Chest·T M JarboeR G Luke

Citations

Aug 1, 1993·Journal of Paediatrics and Child Health·M P DykeR Andrews
Oct 1, 1990·Archives of Disease in Childhood·D P Southall, M P Samuels
Apr 28, 2012·Acta Paediatrica·Robert CottonJeff Reese
Feb 14, 2006·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·D S Semama
Mar 13, 2015·Frontiers in Pharmacology·Anjali Iyengar, Jonathan M Davis
Apr 7, 2005·The Annals of Pharmacotherapy·Marcia L Buck
Apr 28, 2005·Journal of Intensive Care Medicine·Helen Christou, Dara Brodsky
Apr 5, 2002·Clinical Pediatrics·F Fernandez Nievas, V Chernick
Jan 1, 1990·Pediatric Pulmonology·J M DavisJ V Aranda
Jun 1, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D G Sweet, H L Halliday
Sep 9, 2011·The Cochrane Database of Systematic Reviews·Audra StewartIris Ambrosio-Perez
Dec 23, 2018·Clinical Medicine Insights. Pediatrics·Zoe MichaelHelen Christou

Related Concepts

Spiridazide
Bronchopulmonary Dysplasia
Drug Combinations
Eryhem
Sectrazide
Lung
Respiratory Function Tests
Spiro von ct
Urine

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