Effect of spironolactone on p-nitrophenol glucuronidation in isolated rat hepatocytes

Experientia
E E GuibertE A Rodriguez Garay

Abstract

The effect of spironolactone (SP) on p-nitrophenol (PNP) glucuronidation was studied in isolated rat hepatocytes with appropriate viability conditions. A significant increase of protein concentration and PNP glucuronidation was found in the hepatocytes from SP-treated rats. Increased enzyme activity apparently was related to the SP dose. The results favor the conclusion that SP may induce PNP glucuronidation in the hepatocyte.

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Citations

Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R M AgüeroJ L Corchs
Feb 1, 1989·Toxicology Letters·R M Agüero, E E Guibert
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